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中国癌症防治杂志

中国癌症防治杂志 ›› 2013, Vol. 5 ›› Issue (1): 58-61.doi: 10.3969/j.issn.1674-5671.2013.01.15

• 临床研究 • 上一篇    下一篇

HPV6/HPV11型病毒在儿童复发性呼吸道乳头状瘤中的表达

  

  1. 广西医科大学研究生学院；广西医科大学第一附属医院耳鼻咽喉-头颈外科
  • 出版日期:2013-03-25 发布日期:2013-04-07
  • 通讯作者: 温文胜 E-mail:wenwensheng2000@126.com

Expression of HPV6/HPV11 in juvenile onset recurrent respiratory papillomatosis

  • Online:2013-03-25 Published:2013-04-07

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摘要： 目的 研究儿童复发性呼吸道乳头状瘤（juvenile onset recurrent respiratory papillomatosis，JORRP）的患儿首次发病及完全治愈时肿瘤组织中HPV6型和HPV11型病毒含量的表达变化以及其病毒感染率。方法 收集从首次发病到完全治愈的JORRP患儿29例，分别取每例患儿首次发病及治愈时的标本，采用qRT-PCR法分别测定其首次发病及完全治愈时乳头状瘤组织标本中HPV病毒的含量。结果 ①首次发病组与治愈组HPV6型与HPV11型病毒qRT-PCR相对定量结果的差异均无统计学意义（P＞0.05）。②首次发病组与治愈组HPV6型病毒感染的总体阳性率相同（P＞0.05）；HPV11型病毒感染的总体阳性率不同（P＜0.05）。结论 ①完全治愈组与首次发病组的JORRP患儿相比，HPV6型与HPV11型病毒量的表达并无明显变化。②首次发病组的患儿均有HPV11型病毒感染，治愈组的患儿HPV11型病毒感染率有所下降。

关键词: HPV6, HPV11, 儿童复发性呼吸道乳头状瘤, 实时荧光定量PCR

Abstract: Objective To investigate the expression of human papilloma virus 6（HPV6） and HPV11 in juvenile onset recurrent respira-tory papilloma（JORRP） and examine differences in HPV load and infection rate at initial infection and after complete cure. Methods A total of 29 children with JORRP were analyzed by real-time fluorescent quantitative PCR to determine HPV load at initial infection and after complete cure. Results ① HPV6 and HPV11 load did not differ significantly from each other at initial infection or after complete cure （P﹥0.05）.② The rate of HPV6 infection was similar at initial infection and after complete cure（P﹥0.05），while the overall rate of HPV11 infection was different （P﹤0.05）. Conclusion ① HPV6 and HPV11 load did not differ significantly from each other at initial infection or after complete cure.② Children had HPV11 virus at initial infection，and the rate of HPV11 infection declined after complete cure.

Key words: HPV6 , HPV11, JORRP, RT-PCR