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中国癌症防治杂志 ›› 2013, Vol. 5 ›› Issue (2): 154-158.doi: 10.3969/j.issn.1674-5671.2013.02.18

• 临床研究 • 上一篇    下一篇

80例原发性腹膜后肿瘤切除术预后因素的分析

  

  1. 广西医科大学第一附属医院胃肠腺体外科
  • 出版日期:2013-06-25 发布日期:2013-06-27

Prognostic analysis of patients with primary retroperitoneal tumors undergoing surgical resection

  • Online:2013-06-25 Published:2013-06-27

摘要: 目的 探讨原发性腹膜后肿瘤(primary retroperitoneal tumor,PRT)患者手术切除预后的影响因素。方法 回顾性分析2001年6月至2012年6月住院治疗的80例原发性腹膜后肿瘤患者的临床病理资料,采用Kaplan-Meier方法、Cox比例风险回归模型和Log-rank检验,分析影响PRT患者预后的相关因素。结果 本组病例均获随访,中位随访时间为40.4个月,1年、3年、5年累计生存率分别为92.5%、73.1%、67.5%,中位生存时间为67个月。单因素分析显示,手术方式、肿瘤大小、肿瘤性质、有丝分裂数、周围器官侵犯等因素影响PRT患者术后累计生存率(P<0.05)。多因素分析显示,手术方式、肿瘤性质、有丝分裂数、周围器官侵犯等是影响PRT预后的独立影响因素(P<0.05)。结论 手术切除是PRT患者有效的治疗手段,肿瘤性质、手术方式、周围器官侵犯、有丝分裂数是影响PRT预后的独立影响因素。

关键词: 原发性腹膜后肿瘤, 手术切除, 生存率, 预后因素, 回归分析

Abstract: Objective To explore the prognostic factors of patients with primary retroperitoneal tumor(PRT) treated by surgical re-section. Methods We retrospectively analyzed 80 patients with PRT treated in the First Affiliated Hospital of Guangxi Medical Uni-versity between June 2001 and June 2012.Survival and prognosis were analyzed using the Kaplan-Meier method,the Cox proportional hazard model and the log-rank test. Results All patients were followed up for a median of 40.4 months, and the 1-, 3-, and 5-year cumulative survival rates were 92.5%,73.1% and 67.5%.Median survival time was 67 months. Univariate analysis identified the fol-lowing significant predictors of survival(P<0.05): surgical method,tumor size,tumor characteristics,mitotic counts of tumor cells,and invasion of adjacent organs.Multivariate analysis identified the following independent prognostic factors(P):surgical method,tumor <0.05characteristics,mitotic counts of the tumor cells and invasion of adjacent organs. Conclusion Surgical resection is the most ef-fective treatment for PRT.Tumor characteristics, surgical method,invasion of adjacent organs and mitotic counts of tumor cells are the most important prognostic factors for PRT.

Key words:  Primary retroperitoneal neoplasms, Surgical resection, Survival rate, Prognosis, Regression analysis