关键词: 转化生长因子&beta, 1, 基因多态性, 乙型肝炎, 肝硬化, Meta分析

Abstract:

Objective To meta-analyze the literature on possible correlation of TGF-β1 polymorphism with cirrhosis after Hepatitis B infection in China. Methods Relevant case-control studies were identified in PubMed，Cochrane Library，EMbase，CNKI，CBM，and WanFang databases，and data were meta-analyzed using RevMan 5.3. Results A total of five studies involving 586 cases were identified. Meta-analysis suggests that presence of cirrhosis after  Hepatitis B infection is not significantly associated with the -509 genotype（OR＝1.04，95%CI：0.79-1.36），the T allele at-509 （OR＝1.09，95%CI：0.92-1.28），the T allele at-869 （OR＝1.02，95%CI：0.82-1.27），or the-869 genotype （OR＝1.61，95%CI：1.17-2.21）. No significant publication bias was found. Conclusion Genotypes or alleles at the TGF-β1 polymorphisms-509 and -869 are not significantly associated with occurrence of cirrhosis after  Hepatitis B  infection in China.

Key words: TGF-β1, Polymorphism, Hepatitis B, Cirrhosis, Meta-analysis