关键词: 前列腺癌, GOLM1, 生物信息学, Oncomine数据库, TCGA数据库

Abstract:  Objective To investigate the expression of GOLM1 gene in prostate cancer and its clinical significance. Methods The Oncomine database was used to analyze the expression of GOLM1 gene in prostate cancer and normal prostate tissues. RNA-Seq data and clinical data downloaded from TCGA data，was analyzed the correlation between GOLM1 gene expression and clinicopathological features and prognosis. Results The analysis of Oncomine and TCGA databases showed that the expression of GOLM1 gene in prostate cancer tissues was significantly higher than that in normal prostate tissues（P<0.001）. By analyzing the clinical data in 547 patients，it was found that the expression level of GOLM1 gene was not significantly correlated with age，Clinical T stage，Pathological T stage，and Gleason score. Kaplan-Meier analysis found that low expression of GOLM1 gene patients with overall survival was significantly longer than those with high expression（HR=4.50，95%CI：3.77-5.37，P=0.038）. ROC curve analysis showed that the best cutoff point was 8.889，the sensitivity was 80.5%，the specificity was 80.8%，and the area under the ROC cwrve was 0.530（95%CI：0.813-0.912）. Conclusions The GOLM1 gene is highly expressed in prostate cancer tissues and its expression level is related to poor prognosis. GOLM1 mRNA can be used as a candidate prostate cancer marker.

Key words: Prostate cancer, GOLM1, Bioinformatics, Oncomine, TCGA