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中国癌症防治杂志

中国癌症防治杂志 ›› 2019, Vol. 11 ›› Issue (2): 163-168.doi: 10.3969/j.issn.1674-5671.2019.02.14

• 临床研究 • 上一篇    下一篇

康复新液防治恶性肿瘤放疗所致放射性食管炎疗效的Meta分析

  

  1. 广西中医药大学护理学院；广西壮族自治区人民医院放疗病区
  • 出版日期:2019-04-25 发布日期:2019-05-29
  • 通讯作者: 陈玲。E-mail：181135005@qq.com
  • 基金资助:
    广西壮族自治区卫生和计划生育委员会自筹经费科研课题（Z20180769）

Meta-analysis of the efficacy of Kangfuxin liquid in the prevention and treatment of radiation esophagitis caused by radiotherapy for malignant tumors

  • Online:2019-04-25 Published:2019-05-29
  • Contact: CHEN Ling. E-mail：181135005@qq.com

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摘要： 目的  评价康复新液对恶性肿瘤放疗引起的放射性食管炎的疗效。方法 计算机检索Medline、PubMed、CNKI、WanFang Date、VIP等数据库，搜索康复新液防治恶性肿瘤放疗所致放射性食管炎的临床对照试验，检索期限为建库至2018年12月。根据纳入和排除标准筛选文献，提取资料和质量评价，采用RevMan 5.0软件进行Meta分析。结果 最终纳入6篇文献，合计样本量为482例，其中采用康复新液（试验组）237例，常规健康教育或综合西药疗法（对照组）245例。Meta分析结果显示，试验组和对照组Ⅰ级、Ⅲ级及以上放射性食管炎发生率差异均无统计学意义（RR=1.36，95%CI：0.96~1.95，P=0.09；RR=0.22，95%CI：0.04~1.25，P=0.09）；但试验组Ⅱ级放射性食管炎发生率低于对照组，差异有统计学意义（RR=0.53，95%CI：0.37~0.77，P=0.0006）；试验组放射性食管炎毒性积分亦低于对照组，差异有统计学意义（MD=-0.31， 95%CI：-0.47~-0.16，P<0.0001）。结论 在恶性肿瘤放疗过程中，康复新液可有效降低Ⅱ级放射性食管炎的发生率，但对降低Ⅰ级和Ⅲ级及以上放射性食管损伤无明显优势。

关键词: 康复新液, 放疗, 放射性食管炎, Meta分析

Abstract: Objective To evaluate the efficacy of Kangfuxin Liquid in radioactive esophagitis caused by radiotherapy for malignant tumors. Methods Medline，PubMed，CNKI，WanFang Date and VIP databases were searched to find clinical controlled trials of Kangfuxin liquid for prevention and treatment of radiation esophagitis caused by radiotherapy for malignant tumors from inception to December 2018. According to the inclusion and exclusion criteria，screened the literature，extracted data and evaluated the quality. Meta-analysis was performed by RevMan 5.0 software. Results A total of 6 literatures were included，involving 482 patients of whom，237 cases of Kangfuxin liquid（experimental group） and 245 cases of conventional comprehensive western medicine therapy or routine health education（control group）. Meta-analysis showed that there were no significant differences in the incidence of grade Ⅰ，grade Ⅲand above lesions between the experimental group and the control group（RR=1.36，95%CI：0.96-1.95，P=0.09；RR=0.22，95%CI：0.04-1.25，P=0.09）. However，the incidence of grade Ⅱ injury in the experimental group was lower than that in the control group，and the difference was statistically significant（RR=0.53，95%CI： 0.37-0.77，P=0.0006）. The toxicity score of radioactive esophagitis in the experimental group was also significantly lower than that in the control group（MD=-0.31， 95%CI：-0.47--0.16，P<0.0001）. Conclusion In the course of radiotherapy for malignant tumors，the Kangfuxin liquid can effectively reduce the incidence of grade Ⅱ injury of radiation esophagitis，but there is no obvious advantage in reducing the damage of grade Ⅰ，grade Ⅲ and above lesions.

Key words: Kangfuxin liquid, Radiotherapy, Radioactive esophagitis, Meta-analysis

中图分类号: 

  • R730.5