微信公众号

官网二维码
中国癌症防治杂志

中国癌症防治杂志 ›› 2019, Vol. 11 ›› Issue (4): 323-326.doi: 10.3969/j.issn.1674-5671.2019.04.10

• 临床研究 • 上一篇    下一篇

术前血清前白蛋白水平与甲胎蛋白阴性肝细胞癌患者预后的关系

  

  1. 广西医科大学附属肿瘤医院超声科；广西医科大学第二临床医学院；广西医科大学附属肿瘤医院肝胆外科
  • 出版日期:2019-08-25 发布日期:2019-09-17
  • 通讯作者: 李航 E-mail：lihang58@126.com
  • 基金资助:
    国家自然科学基金项目（81860512）；广西自然科学基金项目（2018GXNSFAA138006）；广西高校中青年教师基础能力提升项目（KY2016YB082）

Correlation between serum prealbumin and prognosis in patients with alpha-fetoprotein-negative #br# #br# hepatocellular carcinoma#br#

  • Online:2019-08-25 Published:2019-09-17

PDF (PC)

591

赞

摘要： 目的 探讨术前血清前白蛋白（prealbumin，PA）对甲胎蛋白阴性的肝细胞癌（alpha-fetoprotein-negative hepatocellular carcinoma，AFP-NHCC）患者预后的影响。方法 回顾性分析2014年1月至2015年12月于广西医科大学附属肿瘤医院接受肝切除术的118例AFP-NHCC患者的临床资料。根据PA临界值将患者分为低PA组（<170 mg/L）和高PA组（≥170 mg/L），采用Cox回归分析术前血清PA水平与AFP-NHCC患者预后的关系。结果 术前血清PA水平与肿瘤直径、大血管侵犯、Child-Pugh分级和BCLC分期有关（P<0.05）。Kaplan-Meier 生存分析结果显示，低PA组患者的中位生存时间较高PA组短（24.5 个月vs 36.0个月，χ2=11.689，P=0.001）。Cox 回归分析显示，低PA组的死亡风险大于高PA组（HR=2.779， 95%CI：1.406~5.492，P=0.003），控制潜在混杂因素后这种关系依然存在。结论 术前血清低前白蛋白水平与 AFP-NHCC患者不良预后有关，可作为评估预后的指标。

关键词: 肝细胞癌, 肝切除术, 前白蛋白, 甲胎蛋白, 预后

Abstract: Objective To investigate the effect of preoperative serum prealbumin（PA） on the prognosis of patients with alpha-fetoprotein-negative hepatocellular carcinoma（AFP-NHCC）. Methods A retrospective cohort study method was performed to collect 118 AFP-NHCC patients from Guangxi Medical University Cancer Hospital from January 2014 to December 2015. According to the preoperative serum PA content demarcation value，118 AFP-NHCC patienbs were divided into low PA group（<170 mg/L） and high PA group（≥170 mg/L）. Cox regression analysis was used to analyze the relationship between preoperative serum PA level and prognosis of patients with AFP-NHCC. Results Preoperative serum PA levels were associated with tumor diameter，macrovascular invasion，Child-Pugh classification，and BCLC stage（P<0.05）. Kaplan-Meier survival analysis showed that the median survival time was lower in the low PA group than that in the high PA group（24.5 months vs 36.0 months， χ2=11.689，P=0.001）. Cox regression analysis showed that patients with AFP-NHCC in the low PA group had a higher risk of death than those in the high PA group（HR=2.779，95%CI：1.406-5.492，P=0.003）， and this relationship persisted after controlling for potential confounders. Conclusion Preoperative serum low PA levels are associated with poor prognosis in patients with AFP-NHCC and can be used as an indicator of prognosis.

Key words: Hepatocellular carcinoma, Hepatectomy, Prealbumin, Alpha-fetoprotein, Prognosis

中图分类号: 

  • R735.7