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中国癌症防治杂志

中国癌症防治杂志 ›› 2019, Vol. 11 ›› Issue (5): 403-407.doi: 10.3969/j.issn.1674-5671.2019.05.08

• 临床研究 • 上一篇    下一篇

中性粒细胞与淋巴细胞比值评估老年中晚期宫颈鳞状细胞癌患者同放化疗的疗效及预后的价值

  

  1. 青岛市中心医院妇科，妇瘤科，胸外科
  • 出版日期:2019-10-25 发布日期:2019-11-26

The evaluating value of neutrophil to lymphocyte ratio on efficacy and prognosis of concurrent chemo-radiotherapy in elderly patients with advanced cervical squamous cell carcinoma

  • Online:2019-10-25 Published:2019-11-26

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摘要： 目的 探讨老年中晚期宫颈鳞状细胞癌患者治疗前中性粒细胞与淋巴细胞比值（NLR）与同步放化疗疗效及预后的关系。方法 回顾性分析2014年1月至2018年12月青岛市中心医院行同步放化疗的103例老年中晚期（ⅡB~ⅢB期）宫颈鳞状细胞癌患者的临床资料，分为高NLR组（NLR≥3.48）和低NLR组（NLR＜3.48），比较两组疗效，并分析影响预后的因素。 结果 高NLR组有效率明显低于低NLR组（57.69% vs 84.31%，χ2=8.840，P=0.004）。NLR与患者年龄、病灶大小、组织分化程度无关（P>0.05），与FIGO分期和淋巴结转移有关（P<0.05）。高NLR组中位OS低于低NLR组（24.0个月 vs 46.0个月，χ2=7.187，P=0.007）。多因素Cox回归分析显示，NLR≥3.48是影响老年中晚期宫颈癌鳞状细胞患者OS的独立危险因素（HR=1.937，95%CI：1.086~3.456，P=0.025）。结论 老年中晚期宫颈鳞状细胞癌患者治疗前NLR高同步放化疗疗效较差，预后不良。

关键词: 宫颈鳞状细胞癌, 中性粒细胞与淋巴细胞比值, 老年, 预后

Abstract: Objective To investigate the relationship between neutrophils to lymphocytes ratio（NLR） and concurrent chemotherapy（CCRT） and prognosis in elderly patients with advanced cervical squamous cell carcinoma. Methods A retrospective analysis was performed in 103 elderly patients with advanced cervical squamous cell carcinoma（stage Ⅱ B-ⅢB） who underwent CCRT in Qingdao Central Hospital from January 2014 to December 2018. The patients were divided into high NLR group（NLR≥3.48） and low NLR group（NLR＜3.48）. The efficacy of CCRT between the two groups were compared，and the factors affecting prognosis were analyzed. Results The clinical efficacy of the high NLR group was statistically significantly lower than that of the low NLR group（57.69% vs 84.31%，χ2=8.840，P=0.004）. NLR was not related to age，size of tumor and degree of histological differentiation（P>0.05），but related to FIGO stage and lymph node metastasis（P<0.05）. The median OS of the high NLR group was lower than that of the low NLR group （24.0 months vs 46.0 months，χ2=7.187，P=0.007）. Multivariate Cox regression analysis showed that NLR≥3.48 was an independent risk factor for OS in elderly patients with advanced cervical squamous cell carcinoma（HR=1.937，95%CI：1.086-3.456，P=0.025）. Conclusions In elderly patients with advanced cervical squamous cell carcinoma with high NLR values before treatment, concurrent chemoradiotherapy is less effective，which is suggested a poor prognosis.

Key words: Cervical squamous cell carcinoma, Neutrophils to lymphocytes ratio, Elderly patient, Prognosis

中图分类号: 

  • R737.33