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中国癌症防治杂志

中国癌症防治杂志 ›› 2020, Vol. 12 ›› Issue (4): 435-440.doi: 10.3969/j.issn.1674-5671.2020.04.13

• 临床研究 • 上一篇    下一篇

Cyclin D1、MMR、FIB与结肠癌预后的相关性分析

  

  1. 广西中医药大学第一附属医院病理科；广西中医药大学第一附属医院仙葫院区普外科；广西医科大学附属肿瘤医院胃肠外科
  • 出版日期:2020-08-25 发布日期:2020-09-01
  • 通讯作者: 曹邦伟 E-mail：oncology@ccmu.edu.cn
  • 基金资助:
    2018 年度消化内科学科协同发展中心特色项目（XXT01）

Correlation analysis of Cyclin D1，MMR，FIB and prognosis of colon cancer

  • Online:2020-08-25 Published:2020-09-01

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摘要： 目的 分析细胞周期蛋白D1（Cyclin D1）、错配修复蛋白（mis-match repair，MMR）、纤维蛋白原（fibrinogen，FIB）与结肠癌预后的关系。方法 回顾性分析210例结肠癌根治术患者的临床病理资料。采用免疫组化法检测Cyclin D1、MMR的表达，凝固法检测静脉血中FIB的浓度，并分析三者与结肠癌患者术后生存的关系。结果 Cyclin D1低表达的结肠癌患者1年、3年、5年生存率均高于高表达患者（Log-rank χ2=9.878，P=0.002）；错配修复基因缺失（mis-match repair genes deletion，dMMR）的患者1年、3年、5年生存率亦较错配修复基因完整（mis-match repair genes complete，pMMR）患者高（Log-rank χ2=5.138，P=0.023）；术前FIB正常的患者1年、3年、5年生存率高于FIB异常患者（Log-rank χ2=9.490，P=0.002）。Cyclin D1高表达、FIB异常为结肠癌预后的独立危险因素（HR=1.931， 95%CI：1.131~3.296；HR=2.029，95%CI：1.170~3.519）。结论 Cyclin D1高表达、pMMR及术前FIB异常的结肠癌患者预后不良。

关键词: 结肠癌, Cyclin D1, MMR, FIB, 预后

Abstract:  Objective To analyze the relationship among Cyclin D1，mis-match repair （MMR），fibrinogen （FIB） and the prognosis of colon cancer. Methods The clinicopathological data of 210 patients undergoing radical resection of colon cancer were retrospectively analyzed. The expression of Cyclin D1 and MMR were detected by immunohistochemistry，the concentrations of FIB in venous blood were detected by coagulation，and the relationship between the three indicators and postoperative survival of colon cancer  patients was analyzed. Results The 1-year，3-year，5-year survival rates of colon cancer  patients with low Cyclin D1 expression were higher than those with high expression groups（Log-rank χ2=9.878，P=0.002）. The 1-year，3-year，5-year survival rates of patients with mis-match repair genes deletion （dMMR） were higher than those with mis-match repair genes complete （pMMR） （Log-rank χ2=5.138，P=0.023）. The 1-year，3-year，5-year survival rates of patients with normal FIB before surgery were higher than those with abnormal FIB（Log-rank χ2=9.490，P=0.002）. The high expression of Cyclin D1 and abnormal FIB were independent risk factors for the prognosis of colon cancer（HR=1.931，95%CI：1.131-3.296；HR=2.029，95%CI：1.170-3.519）. Conclusions Colon cancer patients with high Cyclin D1 expression，pMMR and abnormal FIB before surgery have poor prognosis.

 

Key words:  , Colon cancer；Cyclin D1；MMR；FIB；Prognosis

中图分类号: 

  • R735.2