关键词: 神经内分泌癌, 鼻咽部, 淋巴结转移, 临床特征, 预后

Abstract: Objective To investigate the clinicopathologic features，immunohistochemical characteristics，treatment and prognosis of neuroendocrine carcinoma（NEC） of nasopharynx. Methods The clinical and pathological data of 12 NEC patients were retrospectively analyzed，and relevant literature was reviewed. Results Among the 12 patients，10 were males and 2 were females，with an average age of 49.42 years. The pathologic types were all small cell type NEC. Under electron microscope，small tumor cells could be seen，which were round，oval and fusiform shaped，respectively，with hyperchromatic nuclei，less cytoplasm and high nucleolar ratio，accompanied by obvious pathological mitosis and fine chromatin. Immunophenotype：CgA，Syn，CD56，EBERs positive or partially positive were 6 cases，10 cases，9 cases，and 3 cases，respectively. There were 1 case in stage Ⅰ，1 case in stage Ⅱ，4 cases in stage Ⅲ，5 cases in stage Ⅳ，and 1 case in unknown clinical stage. All patients received radiotherapy and/or chemotherapy，and 9 cases survived and 3 cases died in the end of follow-up. Conclusions Neuroendocrine carcinoma of nasopharynx is relatively rare clinically，mostly occurring in middle-aged and elderly male. The pathological type is mainly small cell type and prone to cervical lymphatic metastasis. Most of the patients are in the middle and advanced stage at the time of treatment，and the treatment is mainly radiotherapy and chemotherapy.

Key words: Neuroendocrine carcinoma, Nasopharynx, Lymph node metastasis, Clinical characteristics, Prognosis