关键词: Objective To investigate the occurrence and risk factors of second malignant neoplasms (SMNs) in children, adolescents and young adult patients with Hodgkin lymphoma, and to guide health screening strategies. Methods , The data of children, adolescents and young adults diagnosed with Hodgkin lymphoma were collected from the SEER database from January 1985 to December 2019, and the demographic characteristics, clinical features and the occurrence of SMNs were retrospectively analyzed. Univariable and multivariable Cox risk regression were used to analyze the risk factors. Results A total of 25, 529 patients with Hodgkin lymphoma were screened from the SEER database, the mean age was 25 years, 90.4%(23, 071/25, 529) had Classical Hodgkin lymphoma, and 48.5% (12 387/25 529) with clinical stage Ⅱ. SMNs occurred in 1 457 cases (5.7%), mainly in reproductive organ tumors (27.5%), hematologic/immunological organ tumors (17.7%) and head/neck tumors (16.3%). Multivariable Cox regression showed that female (HR=1.465, 95%CI: 1.319-1.628, P<0.001), older patients (21-25 years: HR=1.259, 95%CI: 1.069-1.482, P=0.006, 26-30 years: HR=1.315, 95%CI: 1.116-1.548, P=0.001, 31-39 years: HR=2.034, 95%CI: 1.765-2.344, P<0.001), radiotherapy (HR=1.128, 95CI: 1.011-1.260, P=0.032) were independent risk factors affecting the occurrence of SMNs. Conclusions The risk of SMNs persists after treatment in children, adolescents and young adult with Hodgkin lymphoma. To guide the follow-up and SMNs screening of Hodgkin lymphoma patients after treatment, it is necessary to pay attention to the SMNs risk factors (gender, age and radiotherapy) and balance the survival benefit of treatment with the risk of SMNs.

Abstract: 霍奇金淋巴瘤；第二原发恶性肿瘤；年轻患者；危险因素

Key words: 霍奇金淋巴瘤, 第二原发恶性肿瘤, 年轻患者, 危险因素