肝细胞癌；HLA?DRA蛋白；免疫组织化学法；表达；预后," /> 肝细胞癌；HLA?DRA蛋白；免疫组织化学法；表达；预后,"/> HLA-DRA蛋白在肝细胞癌中的表达及其临床意义

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中国癌症防治杂志

中国癌症防治杂志 ›› 2024, Vol. 16 ›› Issue (1): 84-89.doi: 10.3969/j.issn.1674?5671.2024.01.13

• 临床研究 • 上一篇    下一篇

HLA-DRA蛋白在肝细胞癌中的表达及其临床意义

  

  1. 山东第一医科大学（山东省医学科学院）公共卫生与健康管理学院；山东第一医科大学（山东省医学科学院）临床与基础医学院；山东第一医科大学第二附属医院感染性疾病科；济南市中心医院公共卫生科
  • 出版日期:2024-02-25 发布日期:2024-02-27
  • 通讯作者: 邓阳 E-mail： dengy@sdfmu.edu.cn
  • 基金资助:
    国家自然科学基金青年科学基金项目（82204111）；泰安市科技创新发展项目（2021NS335）

Expression of HLA-DRA protein in hepatocellular carcinoma and its clinical significance

  • Online:2024-02-25 Published:2024-02-27

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摘要：  目的 探讨人类白细胞抗原DRA（human leukocyte antigen⁃DRA，HLA⁃DRA）蛋白在肝细胞癌（hepatocellular carcinoma，HCC）中的表达水平及其与患者临床病理特征和预后的关系。方法 回顾性分析273对HCC组织及其癌旁组织，采用免疫组织化学法检测组织中HLA⁃DRA蛋白的表达水平，比较不同HLA⁃DRA表达水平患者临床病理特征的差异。采用Log⁃rank法对不同HLA⁃DRA表达水平患者的总生存期（overall survival，OS）和无复发生存期（recurrence⁃free survival，RFS）进行比较，并采用Cox比例风险回归分析HCC患者术后OS和RFS的影响因素。结果 HCC组织中HLA⁃DRA蛋白的高表达率低于癌旁组织（39.19% vs 72.89%，χ2=62.927，P<0.001）。HLA⁃DRA表达水平高与甲胎蛋白（alpha fetoprotein，AFP）>400 μg/L、伴有肝硬化、BCLC B/C分期、无包膜/包膜不完整以及微血管侵犯有关（均P<0.05）。HLA⁃DRA高表达的HCC患者OS率（χ2=4.336， P=0.037）和RFS率（χ2=13.396，P<0.001）均高于HLA⁃DRA低表达者。HLA⁃DRA蛋白高表达是HCC患者术后OS（HR=0.657，95%CI：0.492~0.898，P=0.021）及RFS（HR=0.668，95%CI：0.549~0.857，P=0.008）的独立保护因素。结论 HLA⁃DRA在HCC组织的高表达率低于癌旁组织，且其高表达是HCC患者预后的独立保护因素。

关键词: 肝细胞癌；HLA?DRA蛋白；免疫组织化学法；表达；预后')">">肝细胞癌；HLA?DRA蛋白；免疫组织化学法；表达；预后

Abstract: Objective To investigate the expression of human leukocyte antigen⁃DRA (HLA⁃DRA) in hepatocellular carcinoma (HCC) and its relationship with clinicopathological characteristics and prognosis. Methods A total of 273 pairs of HCC tissues and corresponding paracancerous tissues were retrospectively analyzed. The  expression of HLA⁃DRA protein were detected by immunohistochemistry method, and the clinicopathological characteristics of patients with different HLA⁃DRA protein expression levels were compared. The overall survival (OS) and recurrence⁃free survival (RFS) of patients with different HLA⁃DRA expression levels were compared by Log⁃rank method. Cox proportional hazards regression was used to assess the factors affecting OS and RFS of HCC patients after hepatectomy. Results The high expression rate of HLA⁃DRA protein in HCC tissues was lower than that in paracancerous tissues (39.19% vs 72.89%, χ2 =62.927, P<0.001). The high HLA⁃DRA expression level was associated with AFP （alpha fetoprotein）>400 μg/L, cirrhosis, BCLC B/C stage, non⁃capsule/incomplete capsule, microvascular invasion (all P<0.05). The OS rate (χ2 =4.336, P=0.037) and RFS rate (χ2 =13.396, P<0.001) of HCC patients with high HLA⁃DRA expression were higher than those with low HLA⁃DRA expression. High expression of HLA⁃DRA protein was an independent protective factor for postoperative OS (HR=0.657, 95%CI: 0.492-0.898, P=0.021) and RFS (HR=0.668, 95%CI: 0.549-0.857, P=0.008) in HCC patients. Conclusions The high expression rate of HLA⁃DRA protein in HCC tissues is lower than that in paracancerous tissues, and its high expression is an independent protective factor for prognosis of HCC patients.

Key words: Hepatocellular carcinoma, HLA?DRA protein, Immunohistochemistry, Expression, Prognosis

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  • 引用本文

    陈琨, 杨慧, 刘子嘉, 张晓林, 徐卓一, 刘柄, 赵玉宝, 丁璐, 邓阳. HLA-DRA蛋白在肝细胞癌中的表达及其临床意义[J]. 中国癌症防治杂志, 2024, 16(1): 84-89.

    CHEN Kun, YANG Hui, LIU Zijia, ZHANG Xiaolin, XU Zhuoyi, LIU Bing, ZHAO Yubao, DING Lu, DENG Yang. Expression of HLA-DRA protein in hepatocellular carcinoma and its clinical significance[J]. Chinese Journal of Oncology Prevention and Treatment, 2024, 16(1): 84-89.