Objective To investigate the safety and efficacy of associating liver partition and portal vien ligation for staged hepatectomy（ALPPS）for the treatment of huge hepatocellular carcinoma （HCC）. Methods A patient with huge HCC was admitted in June 2014 to the Affiliated Tumor Hospital of Guangxi Medical University and underwent ALPPS. The clinicopathological characteristics and operative outcomes of this patient were compared with the ALPPS literature. Results Preoperative assessment showed a ratio of future liver remnant to standard liver volume of 21.06%. The patient underwent a first-stage operation involving right portal vein ligation and in situ splitting of the liver parenchyma. At 7 d after this operation， the ratio of future liver remnant to standard liver volume was 48.84%. At 13 d after the first operation， the patient underwent a second-stage operation involving right hemihepatectomy. The patient experienced perioperative pleural effusion and ascites， and was discharged without severe postoperative liver failure. During 2-month follow-up， no metastasis or recurrence occurred， and AFP levels remained within the normal range. Conclusion ALPPS may be a new treatment option for patients with liver neoplasm whose future liver remnant volume is too small to allow radical resection. ALPPS is associated with high morbidity and mortality， suggesting the need for careful patient selection.