Abstract: Objective To observe the effect of transcatheter arterial chemoembolization（TACE） combined with cobalt-60 gyro rotating radiation （Gyro Knife） in the treatment of primary liver cancer. Methods Retrospective analysis was performed of 71 patients with primary liver cancer who were treated at our hospital from June 2008 to January 2011 using either TACE alone（n=35） or TACE combined with Gyro Knife（n=36）． Response and survival rates were compared for the two treatments. Results Combination therapy gave a significantly higher response rate（77.8％） than TACE alone（54.3％，P<0.05）．Survival rates were significantly higher in the combination therapy group at various time points：97.2% vs 71.4% at 6 months，83.8% vs 51.4% at 12 months，52.8% vs 34.3% at 18 months，and 41.7% vs 28.6% at 24 months（all P<0.05）．Among the combination therapy group three patients experienced fever and four experienced hepatic toxicity when received gyro knife radiotherapy，no cases of radiation pneumonia or bone marrow suppression were observed in either group. Conclusion TACE combined with Gyro Knife therapy may be safe and effective for treating primary liver cancer.

Key words: Liver neoplasm, Transcatheter arterial chemoembolization, Gyro Knife, Efficacy