Abstract:

Objective To explore the effects of short-term structured psychological education intervention combined with Xiaoyaosan on moderate and severe depression，chemokines CCL2 and inflammatory factors IL-6 in patients with hepatocellular carcinoma during perioperative period. Methods 83 patients included with hepatocellular carcinoma accepted liver resection for the first time from October 2016 to February 2018. General information questionnaire，Hospital Anxiety and Depression Scale（HADS-D），and Patient Health Questionnaire-9 item （PHQ-9） were used to conduct the survey at baseline.Patients with moderate and severe depression were randomly divided into control group（n=42） and observation group（n=41） by SPSS software. The control group was treated with usual care combined with Xiaoyaosan，and the observation group was treated with short-term structural psychological education intervention on this basis. Repeated measures anova was used to compare the HADS-D，PHQ-9 scores and the level of CCL2，IL6 of the two groups at baseline，on day 5 post-surgery and 30 days after surgery. Results The time effect，intergroup effect and interaction effect of the HADS and PHQ-9 scores of the two groups were statistically significant （P<0.05）. The HADS-D and PHQ-9 scores were significantly reduced at 30 d after surgery in the observation group compared with the control group （P<0.001），while the levels of CCL2，IL-6 were significantly lower in the observation group than control group at 30d after surgery（P<0.05）. Conclusions Short-term structural psychological education intervention combined with Xiaoyaosan can effectively alleviate the moderate and severe depression in patients with hepatocellular carcinoma during perioperative period，and down-regulate the levels of CCL2 and IL-6 to promote the postoperative recovery of patients with hepatocellular carcinoma.

Key words: Liver neoplasms, Structural psychological intervention, Xiaoyaosan, Depression, CCL2, IL-6