Abstract:

Objective To investigate the clinical and pathological features，diagnosis，differential diagnosis and prognosis of low-grade endometrial stromal sarcoma（LGESS）. Methods Data on clinicopathology， immunohistochemical detection and follow-up of 8 patients with low-grade endometrial stromal sarcoma were reviewed. Results Patients were aged 36-53 years （average， 46 years）；two had menopause. Tumor diameter was 1-6 cm （average，5 cm）. Microscopy revealed endometrial hyperplasia and stromal cells with a short spindle or oval shape，arranged spirally in concentric circles around the small blood vessels. Invasive growth was observed on the tongue. Immunohistochemistry showed strong，diffuse expression of ER，CD10， and PR in seven cases. One patient was focal positive for SMA and desmin foci. One patient was positive for inhibin foci. All 8 cases were fol-lowed up with no deaths. Conclusion LGESS can be diagnosed based on histopathology and immunohistochemistry. CD10，ER， and PR may be useful markers for differential diagnosis.

Key words: Uterine neoplasms, Endometrial stromal sarcoma, Clinicopathology, Immunohistochemistry, Differential diagnosis