Abstract:

Objective To investigate the expression and its clinical significance of nuclear factor erythroid-2-related factor 2（Nrf2） in peripheral T-cell lymphoma（PTCL）. Methods  Expression of Nrf2 was detected by immunohistochemistry in 24 patients with PTCL and 17 patients with reactive hyperplasia of lymph nodes，and associations between expression level and clinico-pathological features were analyzed. All data were analyzed using SPSS 23.0 software. Results The positive rate of Nrf2 expression was significantly higher in PTCL （41.67%） than in reactive hyperplasia of lymph node tissues （5.88%，P<0.05）. Expression of Nrf2 was related to Ann-Arbor clinical stage and B symptom（P<0.05），while it was unrelated to patient age，gender or LDH（P>0.05）. Conclusions The increased expression of Nrf2 in PTCL suggests that Nrf2 may play an important role in the development of PTCL.

Key words: Peripheral T-cell lymphoma, Nuclear factor erythroid-2-related factor 2, Immunohistochemistry, Clinical significance