Abstract:

Objective To explore the diagnostic value of carbohydrate antigen 125（CA125） serum level combined with neutrophil/lymphocyte ratio（NLR） and platelet/lymphocyte ratio （PLR） for endometrial cancer（EC）. Methods Medical records were collected and analyzed for 291 patients，179 cases of endometrial cancer and 112 cases of normal endometrium. The receiver operating characteristic curve （ROC） and logistic regression equation were used to analyze the diagnostic value of CA125，NLR and PLR ffor EC，and the relationship between CA125  serum level and clinicopathological characteristics were analyzed. Results The CA125 seum level，NLR and PLR were（32.73±58.43） U/mL， 2.40±1.21 and 157.89±70.87 in the endometrial cancer group，which were significantly higher than that in the normal endometrium group（16.06±13.47） U/mL，1.87±0.54 and 138.88±43.07（P<0.05）. Correlation analysis showed that CA125  was significantly positive correlated with NLR（r=0.171，P=0.003） and PLR（r=0.146，P=0.013），and PLR showed a significant positive correlation with NLR（r=0.595，P<0.001）. The AUCs for diagnosing EC：CA125，0.706；NLR，0.648；PLR，0.555；Combination，0.792；while the AUC of three combined showed significantly higher diagnostic accuracy than either serum CA125，NLR and PLR alone（P＜0.05）. Conclusion The accuracy of serum CA125 combined with NLR and PLR for the diagnosis of endometrial cancer is higher than that of single test.

Key words: Uterine neoplasms, Endometrial cancer, Carbohydrate antigen 125, Neutrophil, Lymphocyte, Platelet, Diagnosis