Objective To investigate the clinical pathological characteristics, treatment and prognosis of endometrial metastasis of breast cancer,which is very rare. Methods This retrospective study analyzed the clinical data of 3 patients with endometrial metastasis of breast cancer treated at our hospital,and relevant literature was reviewed. Results Two patients had breast-infiltrating lobular carcinoma,while one patient had invasive ductal carcinoma. Endometrial metastatic lesions had a median diameter of 4.5 cm (range,3-8 cm). Cancer cells from endometrial metastatic lesions were round or oval under the microscope,had dense cytoplasm and showed pleomorphism;tumor cells were arranged in tubular,beam or funicular structures,with lobular structures in some parts. Primary tumors and endometrial metastatic lesions in all three patients were positive for ER,PR and Ki-67,while they showed variable staining for CerbB-2,GCDFP-15 and E-cadherin. Primary tumors and endometrial metastatic lesions were positive for p120 and CK7,but negative for CK5/6,SMA,CD10 and S-100. Conclusions Breast cancer patients with endometrial metastasis are rare and have poor prognosis and short survival time. Diagnosis is based mainly on medical history,pathomorphology and immunophenotype.Staining for ER,PR,CK5/6,CK7,CerbB-2 and GCDFP-15 plays a role in differential diagnosis of uterine endometrial carcinoma in primary and metastatic cancer.

 

Breast neoplasms, Endometrium metastasis, Clinical pathology, Immunohistochemistry, Diagnosis