Abstract: Objective To evaluate the association between prostate stem cell antigen（PSCA） gene rs2976392 polymorphism and sus-ceptibility of gastric cancer in Chinese population. Methods Databases including CKNI，Wanfang，VIP，NCBI，Embase，and Web of Science were searched to identify the literatures concerning the association between PSCA gene rs2976392 polymorphism and susceptibility of gastric cancer in Chinese population from the inception to March 22，2020. Meta-analysis was performed using RevMan 5.3 and Stata 12 software after quality assessment. Results A total of 14 case-control studies from 13 literatures were included，involving 6 618 gastric cancer cases and 6 952 controls. The meta-analysis results of allele model（A vs G），dominant gene model（AA+GA vs GG） and a codominant gene model（AA vs GG） all showed that the PSCA gene rs2976392 polymorphism was associated with an increased risk of gastric cancer in the Chinese population （OR=1.28，95%CI：1.08-1.52，P=0.004；OR=1.35，95%CI：1.27-1.45，P＜0.001；OR=1.51，95%CI：1.03-2.20，P=0.030）. The subgroup analysis showed that all the gene models were associated with an increased risk of gastric cancer in Han population（all P＜0.001），but in Tibetan population，all genetic models showed no obvious correlation（all P＞0.05）. Conclusions PSCA gene rs2976392 polymorphisms is associated with an increasing risk of gastric cancer in  Chinese population，and the risk of gastric cancer in the Han population homozygous for the AA genotype is highest.

Key words: Gastric Cancer, Prostate stem cell antigen, rs2976392, Polymorphism, Meta-analysis