Abstract: Objective To evaluate the short-term clinical efficacy and prognosis of patients with solitary spinal metastases who received en bloc spondylectomy(en bloc). Methods The clinical data of patients with solitary spinal metastasis,  who received en bloc resection in our hospital between January 2017 and September 2019,  were analyzed retrospectively,  including the gender,  age,  lesion location,  primary tumor type,  intraoperative bleeding,  and postoperative surgery complications,  as well as the Frankel neurological function score and KPS functional status score before and after surgery. All patients were followed up every 3 months to assess the local progression-free survival (PFS) and overall survival (OS). Results A total of 28 patients were included in this study,  including 17 male and 11 female. The average operation time was (5.78±0.33) h (range: 4.0-7.5 h),  and the average intraoperative blood loss was (1 867.21±613.84) mL (range: 900-3000 mL); 6 cases of postoperative cerebrospinal fluid leakage and 5 cases of local infection occurred after surgery,  of which 3 cases of infection were patients with cerebrospinal fluid leakage,  and all recovered after treatment. The KPS score and Frankel score were significantly improved after the surgery(all P<0.05). The median follow-up time was 15 months (6-33 months),  the 1-year and 2-year local PFS were 87.1% and 68.8%,  respectively,  and the 1-year and 2-year OS were 72.5% and 42.3%,  respectively. Conclusion En bloc resection is a safe and effective way to treat solitary spinal metastases,  with a low incidence of postoperative complications,  good local control rate,  and a significant improvement in the quality of life.

Key words: CAI Weiluo, , XU Lun, , YAN Wangjun