Abstract: Objective To analyze the effects of high sodium diet on the burden of gastric cancer in China and their developing trends, and to provide reference for the optimization of prevention and treatment strategies for high⁃risk populations of gastriv cancer．Methods Based on the data of global burden of disease study 2019 (GBD 2019), the Joinpoint regression model was used to analyze the mortality rate and disability⁃adjusted life⁃years (DALYs) rate of gastric cancer caused by high sodium diet in China from 1990 to 2019. The average annual percent change (AAPC) and 95% confidence interval (CI) were used to represent the change in composition ratio between adjacent years. Results The death rate and crude mortality rate of gastric cancer caused by high sodium diet among Chinese residents increased from 27 226 cases (accounted for 8.913% of the total death of gastric cancer in China) and 2.300/105 in 1990 to 37 131 cases (accounted for 8.808% of the total deaths of gastric cancer in China) and 2.611/105 in 2019, whereas the DALYs rate decreased from 62.048/105 to 61.434/105. The standardized mortality rate of gastric cancer caused by high sodium diet among Chinese residents decreased by 1.716% year by year, with 1.221% for males and 2.661% for females (all P<0.001) from 1990 to 2019. The standardized DALYs rate decreased by 2.005% year by year, with 1.495% for males and 3.067% for females. The DALYs rate in all age groups showed a downward trend (all P<0.001), and the rate of DALYs decreased most rapidly in the age group of 55-59 (AAPC=-2.547%), and slowly in the age group of 80 and above (AAPC=-0.702%). The standardized DALYs rate of stomach cancer caused by high sodium diet among Chinese residents decreased year by year. The rate of decline was higher than that of low and medium social demographic index (SDI) countries or regions (AAPC=-1.209%, -1.119%), but lower than the global average and the average level of high, medium and medium SDI countries or regions (AAPC=-2.094%, -3.166%, -2.361%, -2.090%). Conclusions The burden of gastric cancer caused by high sodium diet among Chinese residents has decreased year by year, but still on a high level; the level of male are higher than that of female, The elderly male population is the key intervention group, and dietary salt reduction intervention should be strengthened to reduce the burden of gastric cancer.

Key words: Gastric cancer, Disease burden, Disability-adjusted life-years, High sodium diet, Life style