Abstract:

Objective To investigate the effect and safety of celecoxib on radiochemotherapy sensitivity in patients with nasopharyn-geal carcinoma（NPC）. Methods Patients  with nasopharyngeal carcinoma（n=73） were enrolled from  December 2013 to December 2017 and randomly divided into two groups：the control group（n=35） received concurrent chemoradiotherapy，while the experimental group（n=38） received the same chemoradiotherapy in combination with celecoxib. The short-term efficacy and safety were compared between the two groups. Results The complete response rate in the experimental group was significantly higher than that in the control group（57.9% vs  22.9%，χ²=7.849，P=0.005），and the adverse reactions such as gastrointestinal reactions, radiation injury，renal dysfunction，and myelosuppression were  similar between the two groups(P＞0.05). Conclusions Celecoxib combined with radiochem-otherapy show better complete response rate and good short-term efficacy for nasopharyngeal carcinoma，and it is well tolerated.

Key words: Nasopharyngeal neoplasms, Celecoxib, Cox-2 inhibitors, Radiotherapy, Chemotherapy, Sensitizer