Abstract: Objective To analyze the incidence and mortality of liver cancer in Hebei Province and its trend of change, and to provide a scientific basis for the prevention and treatment of liver cancer. Methods The incidence and mortality data of liver cancer obtained from 27 cancer registries of Hebei Province from 2012 to 2016 were collected, and analyzed by areas(urban/rural), gender and age groups. The 2000 national census and Segi's standard population were used to calculate the age?standardized rates. The trends of incidence and mortality of liver cancer in Cixian and Shexian were analyzed by Joinpiont model. Results From 2012 to 2016, a total of 12, 906 cases of liver cancer and 11, 522 deaths were reported in Hebei Province, with a crude incidence and mortality rate of 20.16/105 and 18.00/105, respectively. The incidence and mortality rate of liver cancer had decreased to a certain extent in Hebei Province, with the largest decrease among female and the urban population. The incidence and mortality rate of liver cancer in Cixian and Shexian showed a long?term decrease, but there was still a fluctuation. Conclusions The burden of liver cancer is still serious in Hebei Province, but its incidence and mortality are decreasing. The prevention of liver cancer in rural residents and males should be enhanced for early detection and treatment.

Key words: Liver cancer, Incidence, Mortality, Long?term trend, Cancer registry