Abstract: Objective To analyze the cancer incidence and mortality in Guangxi cancer registration areas in 2015. Methods Data form 26 cancer registration areas were analyzed using methods and data quality control criteria of NCCR. Cancer incidence and mortality stratified by gender，area（urban and rural）and age group were analyzed. Crude rate，age-standardized rate（ASR），cumulative rate （0-74 years old） and truncated rate were calculated. The proportion and rates of 10 common cancers in different groups were also calculated.Age-standardized incidence and mortality rates were calculated using the Chinese population census in 2000 and Segi's population. Results Altogether，the 26 cancer registries（19 urban and 7 rural） covered a total of 9，414，305 people（5，679，778 in urban areas and 3，734，527 in rural areas）. New cancer cases and cancer deaths were estimated to be，respectively，22，644 and 13，737. The incidence and mortality of malignant tumors were 240.53/10⁵ （male 275.63/10⁵，female 202.99/10⁵） and 145.92/10⁵（male 191.62/10⁵，female 97.05/10⁵）. Age-standardized incidence and mortality adjusted by Chinese standard population were 191.79/10⁵ and 112.83/105，and 186.76/10⁵ and 110.91/10⁵ by world standard population，respectively. The cumulative（0-74 years old） incidence and mortality were 21.07% and 12.52%，respectively. The incidence and mortality of malignant tumors in urban areas were 254.16/10⁵ and 146.47/10⁵，and age-standardized incidence and mortality adjusted by Chinese standard population were 203.42/10⁵ and 114.47/10⁵，while the incidence and mortality of malignant tumors in rural areas were 219.79/10⁵ and 145.08/10⁵，and age-standardized incidence and mortality adjusted by Chinese standard population were 175.86/10⁵ and 111.80/10⁵. The top 10 most frequent cancers were lung，liver，breast，colorectum，cervix，stomach，nasopharynx，uterus，prostate and brain tumor，accounting for about 76.90% of all cancer new cases. Cancers of liver，lung，colorectum，stomach，breast，nasopharynx，cervix，esophagus，prostate and leukemia were the leading causes of cancer death，ccounted for about 82.32% of all cancer deaths. Conclusions Cancers of liver，lung，colorectum，stomach，breast，nasopharynx and cervix are the common malignant tumors of incidence and mortality in Guangxi cancer registry areas，which should be the focus of prevention and treatment in Guangxi. In addition，we should pay more attention to prostate cancer and female thyroid cancer due to their rising incidence.

Key words: Cancer registry, Malignant tumor, Incidence, Mortality, Guangxi