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中国癌症防治杂志

中国癌症防治杂志 ›› 2012, Vol. 4 ›› Issue (2): 197-199.doi: 10.3969/j.issn.1674-5671.2012.02.25

• 临床研究 • 上一篇    下一篇

 宫颈高级别病变与HPV感染型别分析

  

  1. 广西医科大学附属肿瘤医院妇瘤科；广西医科大学研究生学院
  • 出版日期:2012-06-25 发布日期:2012-07-03
  • 通讯作者: 高 琨 E-mail:kungaomail@126.com
  • 基金资助:

     广西教育厅科研基金资助项目（201012MS045）

Analysis of HPV type in high-grade cervical lesions

  • Online:2012-06-25 Published:2012-07-03

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摘要： 目的 探讨HPV在宫颈高级别病变中的感染率及感染型别。方法 采用导流杂交法分别检测CINⅡ~Ⅲ 30例和宫颈癌患者160例HPV基因型别，比较HPV感染与宫颈病变的关系。结果 CINⅡ~Ⅲ和宫颈癌患者HPV感染率均为90%，且以单型别感染为主，分别为70.37%（19/27）、81.94%（118/144）；在CINⅡ~Ⅲ中HPV58型、52型感染居多，宫颈癌则以HPV16型、18型感染最常见；无论宫颈鳞癌还是宫颈腺癌，以HPV16型检出率最高。结论 HPV16型、18型是宫颈癌的主要致病型，不同病理类型并无HPV型别上的差异；宫颈上皮高级别内瘤变则以HPV58型、52型感染为主；对HPV58型、52型感染者应重视随访。 

关键词: 人乳头瘤病毒, 宫颈上皮内瘤变, 宫颈癌, 感染

Abstract: Objective To investigate the infection rate and type of human papillomavirus（HPV） in high-grade cervical squamous in-traepithelial lesions. Methods Types of HPV genes were detected using a gene-chip technique in 30 patients with CINⅡ-Ⅲ and 160 patients with cervical cancer.The relationship between HPV infection and cervical lesions was analyzed. Results Rates of HPV infec-tion in both groups were 90%，with 70.31%（19/27） and 81.94%（118/144） being single-type infections. HPV-58 and HPV-52 were the most frequent types among patients with CINⅡ-Ⅲ，while HPV-16 and HPV-18 were the most frequent types among patients with cervical cancer. HPV-16 was detected most frequently in both squamous cell carcinoma and adenocarcinoma. Conclusion HPV-16 and HPV-18 are the major HPV types associated with cervical cancer，while HPV-58 and HPV-52 are the major types associated with high-grade squamous intraepithelial lesions.

Key words: Human papillomavirus, High-grade squamous intraepithelial lesion, Cervical cancer