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中国癌症防治杂志

中国癌症防治杂志 ›› 2011, Vol. 3 ›› Issue (3): 225-228.doi: 10.3969/j.issn.1674-5671.2011.03.12

• 临床研究 • 上一篇    下一篇

实验犬喉全切除并喉功能重建术的麻醉处理

陈美球, 徐志文, 温文胜, 郑实兴, 梁杰珍, 曾曼丽   

  1. 1广西医科大学第一附属医院耳鼻咽喉头颈外科；2广西医科大学研究生学院
  • 出版日期:2011-09-25 发布日期:2011-10-17
  • 通讯作者: 徐志文 E-mail:xuzhiwen3@163.com
  • 基金资助:

    广西自然科学基金资助项目（桂科自0640122；桂科自0832149）

Anesthesia of experimental dogs for total laryngectomy and laryngeal reconstruction

CHEN Mei-Qiu, XU Zhi-Wen, WEN Wen-Sheng, ZHENG Shi-Xing, LIANG Jie-Zhen, ZENG Man-Li   

  • Online:2011-09-25 Published:2011-10-17

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摘要： 目的 探讨犬头颈部外科实验性手术的适宜麻醉方法。方法 成年杂种犬13只，随机分为2组。单纯组（n=7）：首剂3%戊巴比妥钠1ml/kg腹腔注射。复合麻醉组(n=6)：首剂为5%戊巴比妥钠0.25ml/kg与速眠新Ⅱ0.05ml/kg分别肌注。结果 单纯戊巴比妥钠组麻醉显效时间为（19.7±6.2）min，维持时间（119.6±34.6）min，术中追加麻药次数不定，术后恢复差。复合麻醉组显效时间为（5.5±1.8）min，维持时间（112.5±24.3）min，此时追加首次剂量的一半，可延长麻醉时间至少（169.8±20.2）min，术后恢复快。两组麻醉的诱导期差异有统计学意义（P＜0.05）。两组首次维持时间差异无统计学意义（P＞0.05）。两组术中追加次数(P＜0.05)及戊巴比妥钠总量与推荐量比值差异均有统计学意义(P＜0.05)。结论 戊巴比妥钠联合速眠新复合麻醉较单纯使用戊巴比妥钠起效快，术中麻药追加次数少且稳定，麻醉剂用量少，麻醉程度满意，术后恢复快，是更为适宜的喉全切除并喉功能重建术的实验犬麻醉方法。

关键词: 戊巴比妥钠, 速眠新, 麻醉, 犬, 喉癌

Abstract: Objective To explore a proper anesthesia method for laryngeal surgery on experimental dogs.Methods  Thirteen adult dogs undergoing total laryngectomy and laryngeal function reconstruction were divided randomly into two groups.Animals in group A were treated with 3% pentobarbital sodium (1ml/kg，intraperitoneal injection) only.Animals in group B were treated with 5% pentobarbital sodium (0.25ml/kg，intramuscular injection) combined with Sumianxin II (0.05ml/kg，intramuscular injection).Results The treatment in group A showed the anesthesia induction time was（19.7±6.2）min，the maintenance of first anesthesia time was（119.6±34.6）min.It needed several more injections to keep anesthesia during the surgery and had poor postoperative recovery.The treatment in group B showed the induction time was（5.5±1.8）min，the maintenance of anesthesia time was（112.5±24.3）min.Only one more injection with 1/2 dose of the first infection was needed，which prolonged the maintenance of anesthesia time to at least（169.8±20.2）min.The dogs in this group reanimated soon after operation.Between group A and group B，the induction time was significantly different (P＜0.05) while the maintenance time of first anesthesia was not significantly different (P＞0.05).Both of the times of additional injection and the ratio of actual amount vs suggested amount of pentobarbital were significantly different (P＜0.05)Conclusions Pentobarbital sodium combined with Sumianxin appears to be a satisfactory method to anaesthetize dogs for the operation of total laryngectomy and laryngeal function reconstruction.It can decrease induction time，reduce the time and dose of additional anesthetics，and obtain more effective anesthesia and rapid recovery.

Key words: Pentobarbital Sodium, Sumianxin, Anesthesia, Dog, Laryngeal Carcinoma