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中国癌症防治杂志

中国癌症防治杂志 ›› 2011, Vol. 3 ›› Issue (3): 222-225.doi: 10.3969/j.issn.1674-5671.2011.03.11

• 临床研究 • 上一篇    下一篇

唾液腺显像对鼻咽癌放疗后腮腺功能的评价

黄秒, 肖国有, 李党生, 姚忠强, 邓李燕   

  1. 广西医科大学附属肿瘤医院影像学诊断中心
  • 出版日期:2011-09-25 发布日期:2011-10-17
  • 基金资助:

    广西卫生厅科研基金资助课题（Z2009241）

Salivary gland scintigraphy in evaluating parotid function of patients with nasopharyngeal carcinoma after radiotherapy

HUANG Miao, XIAO Guo-You, LI Dang-Sheng, YAO Zhong-Qiang, DENG Li-Yan   

  • Online:2011-09-25 Published:2011-10-17

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825

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被引次数

6

摘要： 目的 探讨唾液腺显像对鼻咽癌放疗后腮腺功能的评价。方法 对40例鼻咽癌行适形调强放疗（30例）及常规放疗（10例）的患者，分别于放疗前、放疗结束时及放疗后5个月作口干程度的比较及唾液腺功能显像检查。结果 放疗结束时患者出现不同程度口干症状，放疗后 5 个月，部分患者口干症状有明显改善。唾液腺受损后腮腺显像图像征象及时间放射性曲线均有变化。放疗结束时腮腺定量分析摄取指数（UI）及分泌指数（EI）均比放疗前低（P＜0.05），但适形调强放疗组的UI及EI均比常规放疗组高（P＜0.05）。结论 适形调强放疗可以有效保护腮腺功能，唾液腺显像可用于监测鼻咽癌放疗后腮腺功能变化。

关键词: 唾液腺显像, 腮腺, 鼻咽癌, 放射治疗

Abstract: Objective To study the feasibility of salivary gland scintigraphy in evaluating parotid function of patients with nasopharyngeal carcinoma (NPC) after radiotherapy. Methods Forty patients with NPC who underwent intensity-modulation radiation therapy  30cases(IMRT) or conventional radiotherapy 10 cases were observed.The level of mouth dryness and parotid function before IMRT，at the end of IMRT and 5 month after IMRT were compared by each other.Results Different degrees of mouth dryness were common at the end of IMRT among the patients，but some of them recovered significantly 5 month after IMRT.The parotid scintigraphy signs between before and after IMRT were different，both of uptake index (UI) and excretion index (EI) after IMRT were significant lower than those of before IMRT (P＜0.05).However，the UI and EI of the patients treated with IMRT were significantly higher than those treated with conventional radiotherapy (P＜0.05).Conclusions IMRT can effectively protect parotid function.Salivary gland scintigraphy is sensitive and feasible for monitoring parotid function of NPC patients after radiotherapy.

Key words: Salivary gland scintigraphy, Parotid, Nasopharyngeal carcinoma, Radiotherapy