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中国癌症防治杂志

中国癌症防治杂志 ›› 2012, Vol. 4 ›› Issue (2): 149-153.doi: 10.3969/j.issn.1674-5671.2012.02.13

• 肝癌专栏 • 上一篇    下一篇

TNF-α基因多态性与广西肝癌家族聚集性的相关性研究

  

  1. 广西医科大学附属肿瘤医院实验研究部；广西医科大学研究生学院
  • 出版日期:2012-06-25 发布日期:2012-07-03
  • 通讯作者: 张春燕 E-mail:zcy2016@yahoo.com.cn
  • 基金资助:

    国家自然科学基金资助项目（30960333）；广西自然科学基金资助项目（桂科自099107Z）；广西卫生厅医疗卫生重点科研课题（重2010117）；广西卫生厅自筹经费科研课题（Z2007175）；广西研究生教育创新计划资助项目（2011105981002M176）

Correlation between TNF-α polymorphisms and family clustering of primary liver cancer in Guangxi

  • Online:2012-06-25 Published:2012-07-03

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摘要： 目的 研究肿瘤坏死因子基因TNF-α-308、TNF-α-238与广西肝癌家族聚集性的关系。方法 在广西肝癌高发区选取12个肝癌高发家族（124例）及与之相对应的12个非肿瘤对照家族（129例）为研究对象，采用SNP芯片技术检测两组中TNF-α-308、TNF-α-238的基因型及等位基因频率。结果 肝癌高发家族组TNF-α-308G/A基因型分布频率高于对照家族组，差异有统计学意义（22.6% vs 11.6%，χ2=5.376， P =0.020）；肝癌高发家族组TNF-α-308A等位基因分布频率亦高于对照家族组，差异有统计学意义（11.3% vs 5.8%，χ2=4.877， P=0.024）。两组TNF-α-238基因型频率及等位基因频率差异均无统计学意义（P >0.05）。结论 TNF-α-308基因多态性可能与广西肝癌家族聚集性相关，携带TNF-α-308A等位基因可能会增加肝癌高发家族成员患肝癌的风险；TNF-α-238基因多态性与广西肝癌家族聚集无统计学关联。

关键词: 肝肿瘤, TNF-&alpha, 单核苷酸多态性, 家族聚集性

Abstract: Objective To explore the correlation between genetic polymorphisms of tumor necrosis factor （TNF-α-308，TNF-α-238） and family clustering of primary liver cancer（PLC） in Guangxi. Methods Blood samples were collected from 124 families with a high incidence of PLC and from 129 control families.Genotype and alleles of TNF-α-308 and TNF-α-238 were determined by SNP microar-ray technology. Results The frequencies of TNF-α-308G/A genotype and TNF-α-308A allele in the PLC-clustering families （22.6%and 11.3%）were significantly higher than those in the control families（11.6% and 5.8%）.However，the two groups showed no statisti-cally significant differences in frequencies of the TNF-α-238 genotype or allele（P>0.05）. Conclusions TNF-α-308 genetic polymorph-ism is associated with susceptibility in families with high PLC incidence in Guangxi.In particular，the TNF-α-308A allele is proba-bly a risk factor for PLC in these families. In contrast，the TNF-α-238 polymorphism may not be associated with family clus-tering of PLC in Guangxi.

Key words: Liver neoplasms, TNF-α, Single nucleotide polymorphism, Family clustering