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中国癌症防治杂志

中国癌症防治杂志 ›› 2012, Vol. 4 ›› Issue (1): 49-52.doi: 10.3969/j.issn.1674-5671.2012.01.12

• 临床研究 • 上一篇    下一篇

非小细胞肺癌患者血清中TGF-β1与VEGF的表达及临床意义

  

  1. 广西医科大学附属肿瘤医院化疗二科；广西医科大学研究生学院
  • 出版日期:2012-03-25 发布日期:2012-04-16
  • 通讯作者: 宋向群 E-mail:xiangquns@163.com
  • 基金资助:

    广西自然科学基金资助项目（桂科自0991233）

Serum levels of TGF-β1 and VEGF in patients with NSCLC and their clinical significance

  • Online:2012-03-25 Published:2012-04-16

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摘要： 目的 探讨NSCLC患者血清中转化生长因子β1（TGF-β1）和血管内皮生长因子（VEGF）的表达及其临床意义。方法 用双抗体夹心酶联免疫吸附法（ELISA）检测58例 NSCLC患者术前血清和29例健康体检者血清中TGF-β1和VEGF的水平，比较两组血清TGF-β1和VEGF表达水平的差异以及与临床病理特征的关系。结果 58例NSCLC患者血清中TGF-β1和VEGF水平均显著高于健康者（P<0.01），血清TGF-β1和VEGF的表达水平与病理分化低、临床分期晚及淋巴结转移呈正相关关系（P<0.01），而与性别、年龄、病理类型等差异均无统计学意义（P>0.05）；血清TGF-β1表达水平与VEGF水平呈正相关（P<0.01）。结论 TGF-β1和VEGF可能共同参与了NSCLC 血管生成的作用，从而促进NSCLC的发生、发展和转移。

关键词: 非小细胞肺癌, 转化生长因子&beta, 1, 血管内皮生长因子

Abstract: Objective To measure serum levels of TGF-β1 and VEGF in patients with non-small cell lung cancer （NSCLC） and determine their clinical significance.Methods Serum levels of TGF-β1 and VEGF were determined by ELISA in 58 patients with NSCLC before surgery and in 29 healthy volunteers.Serum levels were compared between the two groups，and associations of serum levels with clinicopathological features were explored.Results Serum levels of TGF-β1 and VEGF were significantly higher in patients than in controls（P<0.01）.Among patients，serum levels of TGF-β1 and VEGF were higher in patients with poorly differentiated tumors，patients in clinical stage III + IV and patients with lymph node metastasis（P<0.01）.Sex，age and NSCLC pathology were not associated with serum levels of TGF-β1 or VEGF （P>0.05）. Serum levels of TGF-β1 and VEGF were positively correlated in NSCLC patients but not in controls（P<0.05）. Conclusion TGF-β1 and VEGF may participate in NSCLC angiogenesis，and promote the development and/or transfer of NSCLC.

Key words: Non-small cell lung cancer；TGF-&beta, 1；VEGF