Abstract:

Objective To analyze the influence factors of radiation-induced lung injury（RILI） after intensity-modulated radiotherapy in elderly（above 80 years）patients with esophageal squamous carcinoma. Methods Clinical data of 94 elderly （above 80 years） patients with esophageal squamous cell carcinoma who underwent intensity-modulated radiotherapy from May 2014 to October 2016 were analyzed. Influencing factors of RILI were identified using multivariate logistic regression analysis. Results Among the 94 patients，the incidence of RILI was 24.5%（23/94）. Univariate analysis identified the following risk factors： smoking, underlying lung diseases, and lung V₅（P＜0.05）. Multivariate analysis identified lung V5≤55% as a protective factor for RILI（OR=0.072，95%CI：0.017-0.308，P<0.001），and underlying lung disease was a risk factor（OR=11.289，95%CI：2.186-58.312，P=0.004）. Conclusions The incidence of  radiation-induced lung injury is high after intensity-modulated radiotherapy in elderly （above 80 years） patients with esophageal squamous carcinoma.Underlying lung diseases increases incidence risk of RILI，and lung V₅≤55% can effectively reduce the occurrence of RILI.

Key words: Esophageal neoplasms, Squamous cell carcinomas, Intensity-modulated radiation therapy, Radiation-induced lung injury, Influence , factors