Abstract: Objective To analyze the long-term life quality of patients with acute leukemia after allogeneic hematopoietic stem cell transplantation and its influencing factors. Methods The patients with acute leukemia who underwent allogeneic hematopoietic stem cell transplantation in the First Affiliated Hospital of Guangxi Medical University from January 2011 to December 2015 were prospectively recruited as the research subjects, and follow-up was up to June 2020. The case-control study was performed by one-to-one matching the patients with the control group chosen from the healthy population from June 2020 to July 2020 according to age (±2 years), gender, and marital status. The Chinese version of the SF-36 scale was used to evaluate the life quality of patients before transplantation, 1 year after transplantation, and 5 years after transplantation. Multiple linear regression analysis was used to analyze the factors affecting the patients' 5-year quality of life, and to compare with healthy people. Results A total of 104 patients were included in this study. The total score of life quality and all dimensions before transplantation were low, and decreased 1 year after transplantation, and gradually recovered 5 years after transplantation (all P<0.05). However, the life quality was still lower than that of the control group after 5 years (all dimensions P<0.05). Multiple linear regression analysis showed that the age of transplantation ≥32 years (β=-2.52, 95%CI: -3.61 to -1.21, P=0.041), graft versus-host disease (β=-3.25, 95%CI: -6.34 to -0.21, P=0.022) and transplant complications (β=-5.93, 95%CI: -9.71 to -1.24, P=0.037) were associated with poor 5-year life quality. Conclusions The life quality of patients with acute leukemia can be gradually improved after allogeneic hematopoietic stem cell transplantation. Actively taking measures to prevent and treat complications after transplantation will help patients return to the life quality level of healthy people.

Key words:  Acute leukemia, Allogeneic hematopoietic stem cell, Quality of life, Influencing factors