Abstract: Objective To analyze the trends in lung cancer incidence and mortality in Guangxi from 2011 to 2020, and provide evidence⁃based recommendations for development of strategies and measures for lung cancer prevention and control. Methods Utilizing lung cancer registration data from Guangxi cancer registry areas spanning 2011 to 2020, the crude incidence and mortality rates, as well as the age⁃standardized incidence rate by Chinese population (ASIRC), and age⁃standardized mortality rate by Chinese population (ASMRC) , were calculated. The Joinpoint regression model was used to analyze the temporal trends in lung cancer incidence and mortality, facilitating the calculation of  the annual percentage change (APC). Results In 2020, Guangxi recorded 16,035 new cases and 13,298 deaths of lung cancer. The crude incidence and ASIRC were 41.11/10⁵ and 30.02/10⁵, respectively, while the crude mortality and ASMRC were 34.10/105 and 24.32/10⁵, respectively. Among men, both the ASIRC (41.60/10⁵ vs 18.93/105) and the ASMRC (36.00/105 vs 13.22/10⁵) were higher than those among women, and both increased with age. From 2011 to 2020, there was a significant downward trend in the ASIRC and ASMRC of lung cancer in Guangxi, with average annual decreases of 3.45% (APC=-3.45%, 95%CI: -4.54% to -2.35%) and 3.10% (APC=-3.10%, 95%CI: -4.92% to -1.24%) , respectively. The trends of ASIRC and ASMRC across different gender and age groups were consistent with the overall trend. Conclusions Although here has been a decline in the incidence and mortality rates of lung cancer in Guangxi from 2011 to 2020, the disease burden remains substantial. It is imperative to enhance public awareness regarding cancer prevention and to implement comprehensive intervention strategies to reduce the burden of lung cancer.

Key words: Lung cancer, Incidence, Mortality, Temporal trends