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Chinese Journal of Oncology Prevention and Treatment ›› 2015, Vol. 7 ›› Issue (4): 255-259.doi: 10.3969/j.issn.1674-5671.2015.04.04

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Liquid-based cytology screening for cervical cancer in Lanling district

  

  • Online:2015-08-25 Published:2015-09-08

Abstract:

 Objective To screen married women in Lanling District for cervical cancer using liquid-based cytology testing (LCT). Methods Married women in Lanling district were enrolled into this study in the first half of 2015 based on stratified cluster sampling. Samples were stained by the pap method,analyzed by LCT and diagnosed based on the Tethesda system. Results Screening was completed for 99.96% of the 13,832 samples. Of the 13,832 samples analyzed,90 (0.72%) showed Candida albicans infection;120 (0.87%),vaginal trichomoniasis;30 (0.22%),actinomycosis;and 770 (5.57%),bacterial vaginosis. A total of 1,019 women (7.37%) showed microbial infections and 834(6.03%) showed cell abnormalities. Women with such abnormalities,most of whom were between 25 and 55 years old, included 479 (3.46%) with atypical squamous cells (ASC) of unknown significance (ASC-US),25 (0.18%) with atypical squamous cells that might correspond to high-grade squamous intraepithelial lesions(HSIL,ASC-H),235 (1.70%) with low-grade squamous intraepithelial lesions (LSIL),90 (0.65%) with HSIL,1(0.01%) with squamous cell carcinoma (SCC) and 4(0.03%) with atypical glandular cells(AGC). The ratio of ASC to squamous intraepithelial lesions was 1.546. Cervical biopsy showed that 26 of the 27 women with HSIL had cervical intraepithelial neoplasia Ⅱ or Ⅲ. The diagnostic coincidence rate was 96.3%. Conclusion Cervical LCT can detect a large number of microbial infections and precancerous lesions,suggesting it is effective for cervical cancer screening of
married women.

Key words: Cervical neoplasm, Cervical intraepithelial neoplasia, Cervical liquid-based cytology, Screening