Abstract:

Objective To analyze breast cancer susceptibility gene-1（BRCA1） expression and its clinical significance in prostate carcinoma. Methods BRCA1 expression was analyzed using immunohistochemistry in 46 prostate carcinoma tissue sections and 14 adjacent normal tissue sections. Possible relationships were explored between BRCA1 expression and clinicopathological variables. Results Rate of BRCA1 positivity was 78.6% for adjacent normal tissue， but only 45.7% for prostate carcinoma. BRCA1 expression levels were significantly lower in prostate carcinoma tissues than in adjacent normal tissues（P<0.05）. BRCA1 expression level correlated with family history，Gleason classification and TMN stage（P<0.05），but not with age or prostate-specific antigen （PSA）（P>0.05）. Conclusion Prostate carcinoma is associated with lower BRCA1 expression，and lower expression may correlate with greater tumor malignancy. BRCA1 may be a useful diagnostic and prognostic biomarker in prostate cancer.

Key words: Prostatic neoplasm, Breast cancer susceptibility gene-1, Immunohistochemistry, Clinical significance