Abstract: Objective To explore the effect of individualized analgesia management model with multi-disciplinary collaboration in patients with esophageal cancer after radical resection. Methods Totals of 50 patients who underwent radical resection of esophageal cancer in our hospotal from September 2017 to March 2018 were selected as the control group，and 48 patients from April to September 2018 were selected as the observation group.The traditional analgesic model was used in the control group，while the individualized analgesia management mode of multi-disciplinary cooperation was adopted in the observation group.The rest pain and activity pain score，the first activity time after operation，the number of patient-controlled analgnesia（PCA） pressing，the pump pause rate，the pump renewing rate and the incidence of adverse reactions were compared between the two groups. Results There were no significant difference in the first rest pain score, the mean rest pain score，the maximum rest pain score and the first activity pain score between the two groups（P＞0.05）. However, the mean value and the maximum value of active pain score in the observation group were significantly lower than the control group （P<0.05）. During the use of PCA, the total numbers of PCA pressing，daily PCA pressing and pump renewing rate in the observation group were significantly higher than those in the control group（P<0.001）. However, there was no significant difference in the pump pause rate between the two groups（P>0.05）. The ambulation time of getting out of bed in the observation group was significantly earlier than that in the control group（P<0.05），but there was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）.  Conclusion The individualized analgesia management model with multi-disciplinary collaboration can improve the compliance of patients with analgesic treatment，and effectively control active pain and accelerate recovery.

Key words: Esophageal cancer, Multidisciplinary collaboration, Individualization, Analgesia management