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中国癌症防治杂志

中国癌症防治杂志 ›› 2013, Vol. 5 ›› Issue (4): 300-303.doi: 10.3969/j.issn.1674-5671.2013.04.03

• 流行病学调查 • 上一篇    下一篇

PSCA基因rs2976392位点多态性与胃癌发病的关系

  

  1. 青岛大学医学院；青岛市市立医院急诊科；青岛市市立医院消化内二科
  • 出版日期:2013-12-25 发布日期:2013-12-31
  • 通讯作者: 姜相君 E-mail:drjxj@163.com
  • 基金资助:

    青岛市公共领域科技支撑计划项目（2012-1-3-1-（10）-nsh）

PSCA polymorphism rs2976392 in gastric cancer

  • Online:2013-12-25 Published:2013-12-31

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摘要： 目的 研究PSCA基因（prostate stem cell antigen，PSCA） rs2976392位点多态性与胃癌发病的关系。方法 收集155例汉族胃癌患者与210名健康人群的外周血液样本，提取基因组DNA，采用DNA直接测序法进行PSCA基因rs2976392位点的基因分型。结果 PSCA基因rs2976392位点3种基因型GG型、GA型和AA 型在胃癌组中的频率分别为43.23%、41.94%和14.84%，在对照组中分别为50.95%、41.43%和7.62%。与GG型比较，携带GA型和AA型基因型者胃癌发生的风险性增加，OR分别为1.19（95%CI= 0.77～1.86）（P＞0.05）和2.30（95%CI =1.13～4.66）（P＜0.05）。结论 PSCA基因rs2976392位点AA基因型与中国汉族人群的胃癌发病有关。

关键词: 胃肿瘤, 胃癌, PSCA基因, 基因多态性

Abstract: Objective To investigate the relationship between the rs2976392 polymorphism of the PSCA gene and the risk of gastric cancer. Methods A total of 155 patients with gastric cancer and 210 healthy controls were recruited in Shandong and genotyped at the rs2976392 locus using PCR-based DNA sequence analysis and direct DNA sequencing. Results GG，GA and AA genotypes were identified at the rs2976392 locus， with the following frequencies in patients（and controls）：GG，43.23%（50.95%）；GA， 41.94% （41.43%）；and AA， 14.84%（7.62%）.The risk of gastric cancer was significantly higher in individuals with a GA or AA genotype than in those with a GG genotype（GA：OR 1.19，95%CI 0.77-1.86；AA：OR 2.30，95%CI 1.13-4.66）. Conclusions Polymorphism at the rs2976392 locus of the PSCA gene is associated with the incidence of gastric cancer.

Key words: Stomach neoplasms, Gastric cancer, PSCA gene, Genetic polymorphism