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中国癌症防治杂志

中国癌症防治杂志 ›› 2024, Vol. 16 ›› Issue (2): 172-178.doi: 10.3969/j.issn.1674-5671.2024.02.06

• 癌情监测 • 上一篇    下一篇

2011—2018年广西胃癌流行特征及疾病负担分析

  

  1. 广西医科大学附属肿瘤医院肿瘤防控办公室；广西医科大学公共卫生学院；广西壮族自治区卫生健康委员会肿瘤分子医学重点（培育）实验室（广西医科大学附属肿瘤医院）；区域性高发肿瘤早期防治研究教育部重点实验室（广西医科大学）；广西区域性高发肿瘤早期防治研究重点实验室；广西医科大学附属肿瘤医院胃肠外科
  • 出版日期:2024-04-25 发布日期:2024-05-08
  • 通讯作者: 余红平 E-mail：yuhongping@stu.gxmu.edu.cn

Epidemiological characteristics and disease burden analysis of gastric cancer in Guangxi,2011—2018

  • Online:2024-04-25 Published:2024-05-08
  • Supported by:
    国家自然科学基金地区科学基金项目（82060431）；南宁市青秀区科技计划重点研发计划项目（2022010）；广西医疗卫生适宜技术开放与推广应用项目（S2021022）；2022年度广西高校中青年教师科研基础能力提升项目（2022KY0092）

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摘要： 目的 分析2011—2018年广西胃癌流行特征及疾病负担的时间变化趋势，为制定有效的防控措施提供科学依据。方法 基于2011—2018年广西胃癌的发病和死亡数据，计算粗发病率、粗死亡率、中国人口年龄标准化发病率/死亡率（简称中标发病率/死亡率），以及世界人口年龄标准化发病率/死亡率（简称世标发病率/死亡率），分析2011—2018年广西胃癌流行特征；计算伤残调整寿命年（disability⁃adjusted life⁃years，DALYs）、早死导致的寿命损失年（years of life lost，YLLs）和疾病所致伤残引起的健康寿命损失年（years lived with disability，YLDs），评价2011—2018年广西胃癌疾病负担情况。采用Joinpoint回归模型计算上述指标的平均年度变化百分比（average annual percent change，AAPC），分析胃癌流行特征和疾病负担的变化趋势。结果 2011—2018年广西胃癌中标发病率由2011年的13.33/10万下降至2018年的10.14/10万，呈明显下降趋势（AAPC=-4.06%，P=0.002）；中标死亡率由2011年的9.87/10万下降至2018年的7.90/10万（AAPC=-2.58%，P=0.006）；DALYs率由2011年的161.10/10万下降至2018年的138.50/10万，但变化趋势无统计学意义（AAPC=-0.79%，P=0.366）。2011—2018各年份男性胃癌的中标发病率、中标死亡率和DALYs率均高于女性。男性胃癌的中标发病率和中标死亡率分别以年均2.56%（AAPC=-2.56%，P=0.181）和1.79%（AAPC=-1.79%，P=0.190）的速度下降，但变化趋势均无统计学意义；女性胃癌的中标发病率以年均4.40%的速度变化（AAPC=-4.40%，P=0.002），呈明显下降趋势，中标死亡率以年均3.17%的速度下降（AAPC=-3.17%，P=0.065），但变化趋势无统计学意义。结论 2011—2018年广西胃癌的发病率、死亡率呈下降趋势，但胃癌疾病负担仍处于较高水平，需持续加强胃癌的防治工作，重点对胃癌高危人群开展筛查与早诊早治工作，以期降低胃癌的疾病负担。

关键词: 胃癌, 发病率, 死亡率, 疾病负担, 变化趋势

Abstract: Objective To analyze the temporal variation trend of the epidemiological characteristics and disease burden of gastric cancer in Guangxi from 2011 to 2018, providing a scientific basis for formulating effective prevention and control measures. Methods Based on the incidence and mortality data of gastric cancer in Guangxi from 2011 to 2018, the crude incidence rate, crude mortality rate, age⁃standardized incidence /mortality rate by Chinese standard population (ASIRC /ASMRC), and age⁃standardized incidence/mortality rate by world standard population (ASIRW/ASMRW) were calculated to analyze the epidemiological characteristics of gastric cancer in Guangxi from 2011 to 2018; the disability⁃adjusted life⁃years (DALYs), years of life lost (YLLs) due to premature death, and years lived with disability (YLDs) due to disease were calculated to evaluate the disease burden of gastric cancer in Guangxi from 2011 to 2018. The average annual percent change (AAPC) of the above indexes was calculated by using the Joinpoint regression model to analyze the temporal variation trend of epidemiological characteristics and disease burden of gastric cancer. Results From 2011 to 2018, the ASIRC of gastric cancer in Guangxi decreased from 13.33/105 in 2011 to 10.14/105 in 2018, showed a significant downward trend (AAPC=-4.06%, P=0.002); the ASMRC decreased from 9.87/105 in 2011 to 7.90/105 in 2018 (AAPC=-2.58%, P=0.006); the DALYs rate decreased from 161.10/105 in 2011 to 138.50/105 in 2018, but the trend of change was not statistically significant (AAPC=-0.79%, P=0.366). The ASIRC, ASMRC and DALYs rate of gastric cancer in male were higher than those in female from 2011 to 2018. The ASIRC and ASMRC of gastric cancer in male decreased at an average annual rate of 2.56% (AAPC=-2.56%, P=0.181) and 1.79% (AAPC=-1.79%, P=0.190), respectively, but the trends of change were not statistically significant. The ASIRC of gastric cancer in female changed at an average annual rate of 4.40% (AAPC=-4.40%, P=0.002), showed a significant downward trend, and the ASMRC decreased at an average annual rate of 3.17% (AAPC=-3.17%, P=0.065), but the trend of change was not statistically significant. Conclusions The incidence rate and mortality rate of gastric cancer in Guangxi show a downward trend from 2011 to 2018, but the disease burden of gastric cancer is still at a relatively high level. It is necessary to continuously strengthen the prevention and treatment of gastric cancer, with focus on screening and early diagnosis and treatment for high⁃risk groups of gastric cancer, to reduce the disease burden of gastric cancer.

Key words: Gastric cancer, Incidence, Mortality, Disease burden, Trend of change

中图分类号: 

  • R735.2