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中国癌症防治杂志

中国癌症防治杂志 ›› 2019, Vol. 11 ›› Issue (1): 52-57.doi: 10.3969/j.issn.1674-5671.2019.01.09

• 癌情监测 • 上一篇    下一篇

安徽省2010~2014年卵巢癌发病趋势分析

  

  1. 230601 合肥 安徽省疾病预防控制中心慢病科
  • 出版日期:2019-02-25 发布日期:2019-03-28
  • 基金资助:
    2017年度安徽省重点研究与开发计划项目（1704a0802156）

Trends in incidence of ovarian cancer in Anhui province,2010—2014

  • Online:2019-02-25 Published:2019-03-28

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摘要： 目的 分析2010~2014年安徽省肿瘤登记地区卵巢癌发病趋势。方法 收集2010~2014年安徽省肿瘤登记地区卵巢癌发病资料，计算卵巢癌粗发病率，以及中国人口标化发病率（简称中标率）和世界人口标化发病率（简称世标率）。采用Possion回归模型比较城市及农村地区发病率，Joinpoint回归模型计算卵巢癌发病年度变化百分比（annual percent change， APC）， Joinpoint平行检验比较城市和农村地区卵巢癌年龄别发病率的变化。 结果2010~2014年安徽省肿瘤登记地区新发卵巢癌病例2 050例，粗发病率为6.54/10万，中标率为5.35/10万，世标率为5.12/10万。Possion回归分析结果显示，城市地区发病率高于农村地区（OR=1.2391，95%CI：1.2383~1.2399，P<0.001）。从年龄别发病率来看，在20岁之前卵巢癌发病率较低，20岁后发病率随年龄增长快速上升，总体发病高峰在60岁和70岁年龄组；城市地区卵巢癌发病率在70岁年龄组达到高峰；农村地区卵巢癌发病率在45岁年龄组出现一个小高峰，60岁年龄组达到高峰。Joinpoint检验结果显示，2010~2014年安徽省卵巢癌粗发病率呈上升趋势，变化趋势差异有统计学意义（APC=11.05%，95%CI：5.04%~17.41%，P=0.012），中标率、世标率变化趋势与粗发病率一致；农村地区上升趋势（APC=10.62%，95%CI：4.37%~17.23%，P=0.009）较城市地区（APC=9.01%，95%CI：-0.31%~19.19%，P=0.056）明显。40~59岁年龄组城市和农村地区卵巢癌发病率均呈上升趋势，但城市地区差异无统计学意义（APC=3.81%，95%CI：-8.85%~18.24%，P=0.441），农村地区差异有统计学意义（APC=9.35%，95%CI：6.52%~12.25%，P=0.002）。结论 安徽省卵巢癌发病率呈上升趋势，城市地区发病率高于农村地区，但农村地区发病率上升趋势较城市地区明显，需进一步加强卵巢癌的防控工作，特别是农村地区40~59岁年龄段的女性。

关键词: 卵巢癌, 发病率, 趋势, 年度变化百分比

Abstract: Objective To analyze the trend of incidence of ovarian cancer in Anhui cancer registration areas from 2010 to 2014. Methods Data on ovarian cancer from 2010 to 2014 were obtained from Anhui registries. The crude incidence，age-standardized rate by Chinese standard population in 2000（ASR China），age-standardized rate by Segi's population（ASR world）were calculated. The Possion regression method was used to compare the incidence of urban and rural areas，the Joinpoint regression model was used to calculate the annual percent change （APC） of ovarian cancer，and the Joinpoint parallel test method was used to compare the changes of age-specific incidence of ovarian cancer in urban and rural areas. Results The new cases of ovarian cancer were 2，050 in Anhui cancer registration areas from 2010 to 2014. The crude incidence rate，ASR China，ASR world were 6.54/105，5.35/105，5.12/105 respectively. The Possion regression model result showed that the incidence of ovarian cancer in urban areas was higher than the rural areas（OR=1.2391，95%CI:1.2383-1.2399，P＜0.001）. The incidence of ovarian cancer in all areas was relative low before 20 years old，it increased rapidly after 20 years，and reached the peak at the age group of 60 years and 70 years. The urban areas reached the peak at the age group of 70 years，while the rural areas reached the first peak in age group of 45 years and reached the second peak in age group of 60 years. Joinpoint regression model showed that the crude incidence of ovarian cancer in Anhui province was on the rise from 2010 to 2014，and the difference in the trend was statistically significant（APC=11.05%，95%CI：5.04%-17.41%，P=0.012）. The APC changes of ASR China and ASR world were the same as the crude incidence. The APC of rural areas（APC=10.62%，95%CI：4.37%-17.23%，P=0.009） was higher than that in urban areas（APC=9.01%，95%CI：-0.31%-19.19%，P=0.056）. The incidence of ovarian cancer in urban and rural areas in the 40-59 age group showed an upward trend，the urban areas were not statistically significant（APC=3.81%，95%CI：-8.85%-18.24%，P=0.441），while the rural areas were statistically significant（APC=9.35%，95%CI：6.52%-12.25%，P=0.002）. Conclusions The incidence of ovarian cancer in Anhui Province shows an upward trend. The incidence in urban areas is higher than that in rural areas. However，the rising trend of the incidence in rural areas is more obvious than that in urban areas. It is necessary to further strengthen the prevention and control of ovarian cancer，especially in the 40-59 age group in rural areas.

Key words: Ovarian cancer, Incidence, Trend, Annual percentage change

中图分类号: 

  • R73-31