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中国癌症防治杂志

中国癌症防治杂志 ›› 2019, Vol. 11 ›› Issue (6): 513-517.doi: 1674-5671（2019）06-0513-05

• 临床研究 • 上一篇    下一篇

ERCC1、TYMS和RRM1在宫颈癌组织中的表达及与化疗疗效的关系

  

  1. 广西医科大学附属肿瘤医院妇瘤科，广西医科大学研究生院
  • 出版日期:2019-12-25 发布日期:2020-01-20
  • 通讯作者: 莫凌昭 E-mail：1279512058@qq.com
  • 基金资助:
    广西自然科学基金项目（2016JJA140536）；广西医疗卫生适宜技术开发与推广应用项目（S2019041）

Expression of ERCC1,TYMS and RRM1 in cervical cancer tissues and their relationship with chemotherapy effect

  • Online:2019-12-25 Published:2020-01-20

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摘要： 目的 探讨核苷酸切除修复交叉互补基因1（nucleotide excision repair cross complementary gene1,ERCC1）、胸苷酸合成酶基因（thymidine synthase gene，TYMS）、核苷酸还原酶M1（nucleotide reductase M1,RRM1）在宫颈癌中的表达及其与临床病理特征和化疗疗效的关系。方法 收集2016年1月至2016年12月经术后病理确诊的33例宫颈癌患者的FIGO资料。采用RT-PCR法检测宫颈癌组织中ERCC1、TYMS、RRM1 mRNA的表达，并分析其与临床病理特征及化疗疗效的关系。结果 33例宫颈癌组织中ERCC1、TYMS、RRM1的阳性表达率分别为78.8%、69.7%、75.8%。ERCC1表达与FIGO分期、肿瘤大小、高危型HPV病毒感染、淋巴脉管癌栓、肌层浸润深度、鳞状上皮细胞癌抗原（squamous cell carcinoma antigen，SCC-Ag）水平有关（P<0.05）；TYMS表达与肿瘤大小、高危型HPV病毒感染、淋巴脉管癌栓有关（P<0.05）；RRM1表达与各项临床病理特征均无关（P＞0.05）；ERCC1与TYMS mRNA表达水平呈正相关（r=0.608，P=0.004）。ERCC1、TYMS、RRM1阳性表达患者的化疗总有效率均低于阴性表达患者（P<0.05），3年总生存率亦低于阴性表达患者，但差异无统计学意义（P>0.05）。结论 ERCC1、TYMS、RRM1阳性表达的宫颈癌患者的化疗疗效较差。

关键词: 宫颈癌, 核苷酸切除修复交叉互补基因1, 胸苷酸合成酶基因, 核苷酸还原酶M1, 化疗

Abstract: Objective To investigate the expression of nucleotide excision repair cross complementary gene 1（ERCC1），thymidylate synthetase gene（TYMS） and nucleotide reductase M1（RRM1） in cervical cancer and their relationship with clinicopathological feactures and chemotherapy effect. Methods The clinical data of 33 patients with cervical cancer diagnosed by pathology from January 2016 to December 2016 were collected. The expression of ERCC1，TYMS and RRM1 mRNA in cervical cancer tissues was detected by RT-PCR，and the relationship between ERCC1，TYMS and RRM1 mRNA，clinicopathological features and chemotherapy effect were analyzed. Results The positive rates of ERCC1，TYMS and RRM1 in 33 cases of cervical cancer tissues were 78.8%，69.7% and 75.8%，respectively. The expression of ERCC1 was related to FICG stage，tumor size，high-risk HPV infection，lymphangio-vascular tumor thrombus，myometrial invasion depth，squamous cell carcinoma antigen（SCC-Ag）（P<0.05）； the expression of TYMS was related to tumor size，high-risk HPV infection，lymphangio-vascular tumor thrombus（P<0.05）； the expression of RRM1 was not related to clinicopathological features（P>0.05）. The expression of ERCC1 and TYMS mRNA was positive correlated（r=0.608， P=0.004）. The total effective rate of ERCC1，TYMS and RRM1 positive patients were lower than those of negative patients（P<0.05），and the 3-year overall survival rate were lower than those of negative patients，but the difference was not statistically significant（P>0.05）. Conclusions The patients with ERCC1，TYMS or RRM1 positive expression in cervical cancer have poor chemotherapy effect.

Key words: Cervical cancer, Nucleotide excision repair cross complementary gene 1, Thymidine synthase gene, Nucleotide reductase M1, Chemotherapy

中图分类号: 

  • R737.33