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中国癌症防治杂志

中国癌症防治杂志 ›› 2021, Vol. 13 ›› Issue (1): 62-66.doi: 10.3969/j.issn.1674-5671.2021.01.11

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组蛋白去乙酰化酶2在肝细胞癌组织中的表达及其临床意义

  

  1. 厦门大学附属福州第二医院神经内科；福建医科大学附属肿瘤医院，福建省肿瘤医院病理科；厦门大学附属福州第二医院肝胆内科
  • 出版日期:2021-02-25 发布日期:2021-03-05
  • 通讯作者: 蒋小玲 E-mail271996519@qq.com
  • 基金资助:
    福建省卫生健康科研人才培养项目：青年科研课题（2019-2-28）；福建省卫生健康科研人才培养项目：青年科研课题（2018-1-15）；福州市卫生健康委中青年科学研究项目 （2019-S-wq16）

 Expression of histone deacetylase 2 in hepatocellular carcinoma and its clinical significance

  • Online:2021-02-25 Published:2021-03-05

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摘要： 目的 探讨组蛋白去乙酰化酶2（histone deacetylase 2，HDAC2）在肝细胞癌组织中的表达及其与预后的关系。方法 采用Western blot法和免疫组化检测肝细胞癌组织及对应癌旁组织中HDAC2蛋白的表达情况，并分析其与患者临床病理学参数及预后的关系。结果 HDAC2蛋白在肝细胞癌组织中的表达明显高于癌旁组织（P＝0.025），其表达水平与肿瘤分化程度、脉管侵犯及复发相关（均P<0.05），多因素Cox回归分析显示HDAC2高表达是影响肝细胞癌患者总生存的独立危险因素（HR=12.255，95%CI：2.865~52.411，P＝0.001）。结论 HDAC2在肝细胞癌组织中呈高表达，且高表达患者预后不良，可能是肝细胞癌预后判断潜在的分子标志物。

关键词: 肝细胞癌, 组蛋白去乙酰化酶2, 预后

Abstract: Objective To investigate the expression of histone deacetylase 2(HDAC2) in hepatocellular carcinoma(HCC) tissues and its relationship with prognosis. Methods The expression of HDAC2 protein in hepatocellular carcinoma and corresponding adjacent normal tissues were detected by the Western blot and immunohistochemical methods, and the relationship between the expression level of HDAC2 and clinicopathological parameters and prognosis was analyzed. Results The expression of HDAC2 protein in HCC tissues was significantly higher than that in normal tissues(P=0.025）, and its expression level was correlated with tumor differentiation, vascular invasion and relapse (all P<0.05). Multivariable Cox analysis showed that the high expression of HDAC2 was an independent risk factor for overall survival of patients with hepatocellular carcinoma(HR=12.255, 95%CI:2.865-52.411, P=0.001). Conclusion HDAC2 is highly expressed in HCC tissues, and patients with high expression of HDAC2 have poor prognosis, implying that it can be a molecular marker for prognosis of HCC.

Key words: Hepatocellular carcinoma, Histone deacetylase 2, Prognosis

中图分类号: 

  • R735.7