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中国癌症防治杂志

中国癌症防治杂志 ›› 2021, Vol. 13 ›› Issue (1): 67-71.doi: 10.3969/j.issn.1674-5671.2021.01.12

• 临床研究 • 上一篇    下一篇

沉默调节蛋白4在胃癌组织中的表达及其预后价值

  

  1. 华中科技大学同济医学院附属武汉中心医院肿瘤科
  • 出版日期:2021-02-25 发布日期:2021-03-05
  • 通讯作者: 梅佳 E-mailmeijia0110@qq.com

The expression of sirtuin 4 in gastric cancer and its prognostic value

  • Online:2021-02-25 Published:2021-03-05

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摘要： 目的 探讨沉默调节蛋白4 （sirtuin 4，SIRT4） 在人胃癌组织中的表达及其与患者临床病理特征及预后的关系。方法 回顾性分析2013年10月—2014年10月于武汉市中心医院接受手术治疗的117例胃癌患者的临床资料。采用免疫组化法检测胃癌组织及其相应癌旁组织中SIRT4蛋白的表达，并分析SIRT4表达水平与患者临床病理特征及预后的关系。结果 SIRT4蛋白在胃癌组织中的表达水平低于癌旁组织［（2.138±1.306） 分 vs （9.582±3.243） 分，t=19.078，P<0.001］，且SIRT4蛋白表达水平与肿瘤分化程度、浸润深度、淋巴结转移、淋巴脉管浸润、神经侵犯及TNM分期有关（均P<0.05）。SIRT4低表达组总生存率低于SIRT4高表达组（P=0.001），多因素Cox回归分析显示SIRT4蛋白低表达是影响胃癌患者总生存期的独立危险因素（HR=2.241，95%CI：1.252~4.165，P=0.021）。结论 SIRT4在胃癌组织中低表达且与患者预后不良有关，可能是胃癌患者潜在的预后评估标志物。

关键词: 胃癌, SIRT4, 临床病理特征, 预后

Abstract: Objective To investigate the expression of sirtuin 4(SIRT4) in gastric cancer tissues and its association with clinicopathological characteristics and prognosis of gastric cancer patients. Methods A total of 117 clinical data of gastric cancer patients who underwent surgery in the Central Hospital of Wuhan from October 2013 to October 2014 were retrospectively analyzed. The expression of SIRT4 protein in gastric cancer tissues and its paracancerous tissues were detected by immunohistochemistry, and the associations with SIRT4 expression level and the clinicopathological characteristics and prognosis of gastric cancer patients were analyzed. Results The expression level of SIRT4 protein in gastric cancer tissues was lower than that in paracancerous tissues［(2.138±1.306) points vs (9.582±3.243) points, t=19.078, P<0.001］, and the expression of SIRT4 protein was significantly correlated with the tumor differentiation, tumor invasion, lymph node metastasis, lymphovascular invasion, perineural invasion, and TNM stage(all P<0.05). The overall survival rate of SIRT4 low expression group was significantly lower than that of SIRT4 high expression group(P=0.001). Multivariable Cox analysis showed that SIRT4 protein low expression was an independent risk factor affecting the overall survival of gastric cancer patients(HR=2.241, 95%CI:1.252-4.165, P=0.021). Conclusion SIRT4 is lowly expressed in gastric cancer tissues and associated with poor prognosis of gastric cancer patients, which may be a potential prognostic evaluation marker for gastric cancer patients.

Key words: Gastric cancer, SIRT4, Clinicopathological characteristics, Prognosis

中图分类号: 

  • R735.2