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中国癌症防治杂志

中国癌症防治杂志 ›› 2022, Vol. 14 ›› Issue (4): 385-392.doi: 10.3969/j.issn.1674-5671.2022.04.05

• 癌情监测 • 上一篇    下一篇

2014—2018年广西宾阳县恶性肿瘤发病、死亡和疾病负担及其趋势分析

  

  1. 广西医科大学公共卫生学院流行病与卫生统计学教研室；广西医科大学附属肿瘤医院实验研究部；宾阳县疾病预防控制中心慢病科；广西医科大学附属肿瘤医院肿瘤防控办公室；区域性高发肿瘤早期防治研究教育部重点实验室；广西区域性高发肿瘤早期防治研究重点实验室；广西医科大学附属肿瘤医院胃肠外科
  • 出版日期:2022-08-25 发布日期:2022-09-08
  • 通讯作者: 余红平 E-mail:yuhongping@stu.gxmu.edu.cn；周先果 E-mail: zhouxianguo@stu.gxmu.edu.cn
  • 基金资助:
    广西重点研发计划（桂科 AA18221001）；广西重点研发计划（桂科 AB18050020）；国家自然科学基金地区科学基金项目（82060431）；广西自然科学基金项目（2020GXNSFAA259022）；广西壮族自治区卫生健康委员会肿瘤分子医学重点（培育）实验室（ZPTJ2020001）

Trends of cancer incidence,mortality and disease burden in Binyang county,Guangxi,2014—2018

  • Online:2022-08-25 Published:2022-09-08

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摘要： 目的 分析2014—2018年广西宾阳县恶性肿瘤的发病、死亡和疾病负担及其时间变化趋势，为该县科学制定恶性肿瘤防治策略提供参考。方法 收集2014—2018年广西宾阳县恶性肿瘤发病和死亡数据，计算粗发病率、粗死亡率、中国人口标化发病/死亡率（简称中标发病/死亡率）和世界人口标化率（简称世标发病率/死亡率），分析恶性肿瘤发病和死亡情况。采用伤残损失寿命年（years of lived with disability，YLDs）、过早死亡损失寿命年（years of life lost，YLLs）和伤残调整寿命年（disability-adjusted life years，DALYs）等指标评价恶性肿瘤所致的疾病负担情况。利用Joinpoint回归模型估计恶性肿瘤发病率、死亡率及DALYs率的平均年度变化百分比（average annual percent change，AAPC），评价其变化趋势。结果 2014—2018年广西宾阳县恶性肿瘤共报告新发病例数11 536例，粗发病率为219.64/10万，中标发病率为180.25/10万；共报告死亡病例数6 970例，粗死亡率为132.70/10万，中标死亡率为103.44/10万。2014—2018年广西宾阳县恶性肿瘤粗发病率变化呈增长趋势，但变化差异无统计学意义（AAPC=9.88%，t=2.11，P=0.125）；粗死亡率由2014年的103.08/10万增长至2018年的149.35/10万，平均每年增长10.83%（AAPC=10.83%，t=4.03，P=0.027）。恶性肿瘤发病前10位依次为肝癌、肺癌、女性乳腺癌、结直肠癌、子宫颈癌、胃癌、鼻咽癌、食管癌、脑瘤和甲状腺癌，占全部恶性肿瘤发病的81.33%。恶性肿瘤死亡前10位依次为肝癌、肺癌、胃癌、女性乳腺癌、结直肠癌、鼻咽癌、子宫颈癌、食管癌、脑瘤和白血病，占全部恶性肿瘤死亡的86.11%。2014—2018年广西宾阳县恶性肿瘤造成的DALYs共计108 848.61人年，DALYs率为2 072.40/10万人年。恶性肿瘤DALYs率从2014年的1 637.17/10万人年增长至2018年的2 366.51/10万人年，平均每年增长10.87%（AAPC=10.87%，t=4.72，P=0.018）。DALYs率前10位恶性肿瘤依次为肝癌、肺癌、女性乳腺癌、胃癌、结直肠癌、鼻咽癌、子宫颈癌、脑瘤、白血病和子宫体癌。结论 2014—2018年广西宾阳县恶性肿瘤的发病率、死亡率和DALYs率较高，死亡率和DALYs率呈较快增长趋势。肝癌、肺癌、女性乳腺癌、胃癌、结直肠癌、鼻咽癌和子宫颈癌等是广西宾阳县重点防治的恶性肿瘤。

关键词: 恶性肿瘤, 发病率, 死亡率, 疾病负担, 趋势, 伤残调整寿命年

Abstract: Objective To analyze the developing trends of cancer incidence, mortality and disease burden in Binyang county, Guangxi, from 2014 to 2018, and to provide reference for developing cancer prevention and treatment strategies. Methods The incidence and mortality data of cancer in Binyang county, Guangxi, from 2014 to 2018 were collected, the crude incidence rate, crude mortality rate, age?standardized incidence and mortality rate by Chinese standard population (ASIRC and ASMRC) and world population (ASIRW and ASMRW) were calculated, and the incidence and mortality of cancer were analyzed. The years of lived with disability (YLDs), years of life lost (YLLs) and disability?adjusted life years (DALYs) were used to assess the disease burden caused by cancer. The Joinpoint regression model was used to estimate the average annual percent change (AAPC) of cancer incidence, mortality and DALYs rate, and to evaluate the trends. Results From 2014 to 2018, a total of 11, 536 new cases of cancer were reported in Binyang county, with a crude incidence rate of 219.64/105, anregression model was used to estimate the average annual percent change (AAPC) of cancer incidence, mortality and DALYs rate, and to evaluate the trends. Results d ASIRC of 180.25/105. A total of 6, 970 deaths were reported, with a crude mortality rate of 132.70/105, and ASMRC of 103.44/105. The crude incidence rate of cancer in Binyang county showed an increasing trend from 2014 to 2018, though the difference was not statistically significant (AAPC=9.88%, t=2.11, P=0.125). The crude mortality rate increased from 103.08/105 in 2014 to 149.35/105 in 2018, with an average annual increase of 10.83% (AAPC=10.83%, t=4.03, P=0.027). The cancers of liver, lung, female breast, colorectum, cervix, gastric, nasopharynx, esophagus, brain and thyroid were the top ten for cancer incidence, accounting for 81.33% of the total cancers. The cancers of liver, lung, gastric, female breast, colorectum, nasopharynx, cervix, esophagus, brain and leukemia were the ten leading causes of cancer deaths, accounting for 86.11% of the total cancers. Cancers resulted in 108, 848.61 DALYs in Binyang county from 2014 to 2018, the DALYs rate was 2, 072.40 DALYs per 105 persons. The DALYs rate of cancer increased from 1, 637.17/105 in 2014 to 2, 366.51/105 in 2018, with an average annual increase of 10.87% (AAPC=10.87%, t=4.72, P=0.018).The top ten cancers in DALYs rate were the cancers of liver, lung, female breast, gastric, colorectum, nasopharynx, cervix, brain, leukemia and uterus. Conclusions From 2014 to 2018, the incidence, mortality and DALYs rates of cancer in Binyang county, Guangxi province are relatively high, and the mortality and DALYs rates showed a growth trend. The main cancers in Binyang county, include liver cancer, lung cancer, female breast cancer, gastric cancer, colorectal cancer, nasopharynx cancer and cervix cancer, which deserve more prevention and control effort.

Key words: Cancer, Incidence, Mortality, Disease burden, Trend, DALYs

中图分类号: 

  • R73-31