Abstract:

Objective To assess the usefulness of the ratio of gamma-glutamyl transpeptidase to platelets （GPR）for staging hepatic fibrosis in patients with hepatocellular carcinoma（HCC）. Methods Medical records were collected and analyzed for 194 patients who underwent curative liver resection from August 2015 to August 2016 at our hospital. GPR，the ratio index of aminotransferase to platelets （APRI） and the four-factor index （FIB4） were compared for their ability to stage hepatic fibrosis based on the area under the receiver operating characteristic curve. Results Liver fibrosis stage correlated positively with GPR，APRI，FIB4 and ALT，but negatively with PLT （all P＜0.05）. GPR，APRI，FRONS，FIB4，and PLT differed significantly in different stages of liver fibrosis （P＜0.05）. Among patients with liver fibrosis stage > S0，the indices GPR，APRI，FIB4 and PLT showed similar areas under the curve （P＞0.05）. In contrast，among patients with liver fibrosis stages > S1 and S3 ，GPR showed an area under the curve similar to that of APRI and PLT （P＞0.05） but different from that of FIB4（P＜0.05）. The area under the GPR curve was significantly greater than the areas under the APRI and PLT curves（P＜0.05）. Conclusions GPR is simple to calculate from data obtained during routine clinical it can be more accurate for staging liver fibrosis than other indices. It may therefore be useful as a noninvasive index for preoperative staging of hepatic fibrosis in HCC patients.

Key words: Liver neoplasms, Gamma-glutamyl transpeptidase to platelets , Liver fibrosis, Stages