Abstract: Objective To analyze the trend of incidence of ovarian cancer in Anhui cancer registration areas from 2010 to 2014. Methods Data on ovarian cancer from 2010 to 2014 were obtained from Anhui registries. The crude incidence，age-standardized rate by Chinese standard population in 2000（ASR China），age-standardized rate by Segi's population（ASR world）were calculated. The Possion regression method was used to compare the incidence of urban and rural areas，the Joinpoint regression model was used to calculate the annual percent change （APC） of ovarian cancer，and the Joinpoint parallel test method was used to compare the changes of age-specific incidence of ovarian cancer in urban and rural areas. Results The new cases of ovarian cancer were 2，050 in Anhui cancer registration areas from 2010 to 2014. The crude incidence rate，ASR China，ASR world were 6.54/10⁵，5.35/10⁵，5.12/10⁵ respectively. The Possion regression model result showed that the incidence of ovarian cancer in urban areas was higher than the rural areas（OR=1.2391，95%CI:1.2383-1.2399，P＜0.001）. The incidence of ovarian cancer in all areas was relative low before 20 years old，it increased rapidly after 20 years，and reached the peak at the age group of 60 years and 70 years. The urban areas reached the peak at the age group of 70 years，while the rural areas reached the first peak in age group of 45 years and reached the second peak in age group of 60 years. Joinpoint regression model showed that the crude incidence of ovarian cancer in Anhui province was on the rise from 2010 to 2014，and the difference in the trend was statistically significant（APC=11.05%，95%CI：5.04%-17.41%，P=0.012）. The APC changes of ASR China and ASR world were the same as the crude incidence. The APC of rural areas（APC=10.62%，95%CI：4.37%-17.23%，P=0.009） was higher than that in urban areas（APC=9.01%，95%CI：-0.31%-19.19%，P=0.056）. The incidence of ovarian cancer in urban and rural areas in the 40-59 age group showed an upward trend，the urban areas were not statistically significant（APC=3.81%，95%CI：-8.85%-18.24%，P=0.441），while the rural areas were statistically significant（APC=9.35%，95%CI：6.52%-12.25%，P=0.002）. Conclusions The incidence of ovarian cancer in Anhui Province shows an upward trend. The incidence in urban areas is higher than that in rural areas. However，the rising trend of the incidence in rural areas is more obvious than that in urban areas. It is necessary to further strengthen the prevention and control of ovarian cancer，especially in the 40-59 age group in rural areas.

Key words: Ovarian cancer, Incidence, Trend, Annual percentage change