Abstract: Objective To detect the expressions of MMP-9 and TIMP-1 in non-small cell lung cancer (NSCLC),and to explore their relations to metastasis and prognosis of NSCLC.MethodsA tissue chip was made by the samples from 113 cases of NSCLC and 20 cases of inflammatory pseudotumor.The expressions of MMP-9 and TIMP-1 of the tissue chip were detected by immunohistochemical staining.ResultsThe expressions of MMP-9 and TIMP-1 were not significantly related to patient’s age,sex and smoking situation,and tumor’s size,histological type and differentiation.However,the expressions of MMP-9 and TIMP-1 were closely correlated with lymph node metastasis,TNM and life span stages of the patients with NSCLC.ConclusionsThe expressions of MMP-9 and TIMP-1 could serve as parameters for predicting metastasis and prognosis of NSCLC.

Key words: NSCLC, MMP-9, TIMP-1, Immunohistochemistry