Abstract: Objective To analyze the screening and follow⁃up outcomes of liver cancer early diagnosis and treatment program in Fusui County, Guangxi, from 2011 to 2020. Methods A stratified cluster sampling method was employed to enroll the residents aged 35-64 years old for male and 45-64 years old for female， and other residents who were not within this age range but had cases of liver cancer in their immediate family members in Fusui County from 2011 to 2020 as the study subjects. High⁃risk populations of liver cancer were identified through questionnaires and hepatitis B surface antigen (HBsAg) testing. These individuals underwent combined screening via liver ultrasound and alpha fetoprotein (AFP) testing. The compliance of participating in the early diagnosis and treatment of liver cancer program was analyzed, as well as the detection rate, early diagnosis rate, treatment rate and prognosis of liver cancer. Results From 2011 to 2020, a total of 27, 613 high⁃risk groups were assessed in Fusui County, Guangxi, of which a total of 14, 012 people completed combined screening for liver cancer, with a screening participation rate of 50.74%; 120 liver cancer cases were found and diagnosed, with a detection rate of 0.86%. The detection rate of liver cancer in males was significantly higher than that in females (1.12% vs 0.51%, P<0.001). The detection rates of liver cancer in the age groups of 35-44 years old, 45-54 years old, and ≥55 years old were 0.67%, 0.92%, and 1.05%, respectively, and the difference was not statistically significant (P=0.169). Among the 120 cases of liver cancer , the early diagnosis and treatment rates were 60.83% (73/120) and 91.67% (110/120) respectively. Overall 1⁃, 3⁃, and 5⁃year survival rates were 66.67%, 33.33%, and 20.83%, respectively, while early⁃state liver cancer survival rates were 75.34%, 36.99%, and 24.66%, respectively. Conclusions The early diagnosis and treatment program in Fusui County can effectively identifies liver cancer cases, enables timely intervention, and prolongs survival through early diagnosis.

Key words: Liver cancer, Early diagnosis and treatment, Screening, Guangxi