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Chinese Journal of Oncology Prevention and Treatment

Table of Content

    25 December 2009, Volume 1 Issue 04 Previous Issue    Next Issue
    Article
    The serum levels of bFGF and MMP-2 in patients with nasopharyngeal carcinoma and the correlations with tumor invasion and metastasis
    MO Li-gen,LI Zheng-wei,ZHANG Yu-lin,et al.
    2009, 1 (04):  301-303. 
    Abstract ( 130 )   Save
    Objective To investigate the expression levels of basic fibroblast growth factor (bFGF) and matrix metalloproteinase-2 (MMP-2) in patients with nasopharyngeal carcinoma (NPC) and the correlations with NPC invasion and metastasis.Methods The expression levels of bFGF and MMP-2 in serum were determined from 63 patients with NPC,before and after radiotherapy,by Enzyme-linked immunosorbent.The control serums were from 20 healthy check-up people.Results The expression levels of bFGF and MMP-2 before radiotherapy were (5.16±2.28)ng/ml and (164.08±64.61)ng/ml respectively,which were higher than that in healthy control (2.10±0.31) ng/ml and (85.79±6.74) ng/ml respectively,P<0.01),and were also higher than that in the serum from the same patients after radiotherapy (2.51±1.27) ng/ml and (97.42±48.68) ng/ml respectively,P<0.01).The expression levels of bFGF and MMP-2 in NPC patients' serum after radiotherapy were higher than that in the healthy control serum,while there were out of statistic meaning (P>0.05).The expression levels of bFGF and MMP-2 in NPC patients' serum were related to clinical stage,lymphatic metastasis and distant metastasis (P<0.05).The expression levels of bFGF and MMP-2 in NPC patients' serum showed positive relationship with each other (r=0.8748,P<0.01).Conclusion Expression levels of bFGF and MMP-2 might reflect the development,invasion and metastasis of NPC.Combining detection of bFGF and MMP-2 could be applied as important indicators for evaluating the prognosis of NPC.
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    The serum levels of bFGF and MMP-2 in patients with nasopharyngeal carcinoma and the correlations with tumor invasion and metastasis
    MO Li-gen,LI Zheng-wei,ZHANG Yu-lin,et al.
    2009, 1 (04):  301-303. 
    Abstract ( 99 )   Save
    Objective To investigate the expression levels of basic fibroblast growth factor (bFGF) and matrix metalloproteinase-2 (MMP-2) in patients with nasopharyngeal carcinoma (NPC) and the correlations with NPC invasion and metastasis.Methods The expression levels of bFGF and MMP-2 in serum were determined from 63 patients with NPC,before and after radiotherapy,by Enzyme-linked immunosorbent.The control serums were from 20 healthy check-up people.Results The expression levels of bFGF and MMP-2 before radiotherapy were (5.16±2.28)ng/ml and (164.08±64.61)ng/ml respectively,which were higher than that in healthy control (2.10±0.31) ng/ml and (85.79±6.74) ng/ml respectively,P<0.01),and were also higher than that in the serum from the same patients after radiotherapy (2.51±1.27) ng/ml and (97.42±48.68) ng/ml respectively,P<0.01).The expression levels of bFGF and MMP-2 in NPC patients' serum after radiotherapy were higher than that in the healthy control serum,while there were out of statistic meaning (P>0.05).The expression levels of bFGF and MMP-2 in NPC patients' serum were related to clinical stage,lymphatic metastasis and distant metastasis (P<0.05).The expression levels of bFGF and MMP-2 in NPC patients' serum showed positive relationship with each other (r=0.8748,P<0.01).Conclusion Expression levels of bFGF and MMP-2 might reflect the development,invasion and metastasis of NPC.Combining detection of bFGF and MMP-2 could be applied as important indicators for evaluating the prognosis of NPC.
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    Expressions of osteopontin and integrin αv in nasopharyngeal carcinoma and the significant for tumor invasion and metastasis
    LIU Bin,MO Li-gen,LI Zheng-wei,et al.
    2009, 1 (04):  304-306. 
    Abstract ( 175 )   Save
    Objective To investigate the expressions of osteopontin (OPN) and integrin αv (ITGA V) in nasopharyngeal carcinoma (NPC),and to study their influences on the biological behaviors of tumor cells such as invasion and metastasis.Methods The expressions of OPN and ITGA V were detected on 88 cases of NPC tissue and 18 cases of nasopharyngeal inflammation tissue,by immunohistochemistry method.The parameters such as sex,clinical stage,lymphatic metastasis and distant metastasis were compared and analyzed.Results The positive expression rates of OPN and ITGA V in NPC tissue were 53.4% (47/88) and 59.1% (52/88) respectively,which were higher obviously than that in the nasopharyngeal inflammation tissue (P<0.01).The expressions of OPN and ITGA V in carcinoma tissue were related to clinical pathological stage,lymphatic metastasis and distant metastasis (P<0.05),but not related to sex (P>0.05).The expression of OPN was positively correlated with that of ITGA V in NPC tissue (r=0.335,P<0.01).Conclusion OPN and ITGA V may play a synergic role in the process of invasion and metastasis of NPC.The expression of OPN and ITGA V might reflect the biological characteristics of NPC,and could be applied as important indicators for evaluating the prognosis of NPC.
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    Expressions of osteopontin and integrin αv in nasopharyngeal carcinoma and the significant for tumor invasion and metastasis
    LIU Bin,MO Li-gen,LI Zheng-wei,et al.
    2009, 1 (04):  304-306. 
    Abstract ( 55 )   Save
    Objective To investigate the expressions of osteopontin (OPN) and integrin αv (ITGA V) in nasopharyngeal carcinoma (NPC),and to study their influences on the biological behaviors of tumor cells such as invasion and metastasis.Methods The expressions of OPN and ITGA V were detected on 88 cases of NPC tissue and 18 cases of nasopharyngeal inflammation tissue,by immunohistochemistry method.The parameters such as sex,clinical stage,lymphatic metastasis and distant metastasis were compared and analyzed.Results The positive expression rates of OPN and ITGA V in NPC tissue were 53.4% (47/88) and 59.1% (52/88) respectively,which were higher obviously than that in the nasopharyngeal inflammation tissue (P<0.01).The expressions of OPN and ITGA V in carcinoma tissue were related to clinical pathological stage,lymphatic metastasis and distant metastasis (P<0.05),but not related to sex (P>0.05).The expression of OPN was positively correlated with that of ITGA V in NPC tissue (r=0.335,P<0.01).Conclusion OPN and ITGA V may play a synergic role in the process of invasion and metastasis of NPC.The expression of OPN and ITGA V might reflect the biological characteristics of NPC,and could be applied as important indicators for evaluating the prognosis of NPC.
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    Establishment of cancer serum specimen bank and its significance
    YANG Chun,GE Lian-ying,HE Hai-ping,et al.
    2009, 1 (04):  307-309. 
    Abstract ( 144 )   Save
    Objective To establish the bank of serum specimen that are collected from cancer patients,for fully utilizing the resources to study tumor.Methods Blood samples were collected from cancer patients treated in Guangxi Tumor Hospital before and after surgical operation.Specimens of serum,plasma and lymphocytes were separated then.The specimens were deal with liquid nitrogen for 30 minutes and then stored at -80℃.All the specimen-related information was entered into the database which can be inquired at anytime.Results From patients with cancer in esophagus,nasopharynx,lung,stomach,liver,breast,intestine,uterus,ovary and etc,1021 portions of serum,921 portions of plasma and 950 portions of lymphocyte were collected,before and after operation.Conclusions A cancer serum specimen bank and its managements have been established initially,which can provide a service platform for cancer research in the future.
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    Establishment of cancer serum specimen bank and its significance
    YANG Chun,GE Lian-ying,HE Hai-ping,et al.
    2009, 1 (04):  307-309. 
    Abstract ( 65 )   Save
    Objective To establish the bank of serum specimen that are collected from cancer patients,for fully utilizing the resources to study tumor.Methods Blood samples were collected from cancer patients treated in Guangxi Tumor Hospital before and after surgical operation.Specimens of serum,plasma and lymphocytes were separated then.The specimens were deal with liquid nitrogen for 30 minutes and then stored at -80℃.All the specimen-related information was entered into the database which can be inquired at anytime.Results From patients with cancer in esophagus,nasopharynx,lung,stomach,liver,breast,intestine,uterus,ovary and etc,1021 portions of serum,921 portions of plasma and 950 portions of lymphocyte were collected,before and after operation.Conclusions A cancer serum specimen bank and its managements have been established initially,which can provide a service platform for cancer research in the future.
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    Analysis of incidence trend of gastric cancer in Fusui County from 1974 to 2005
    WEI Zhong-liang,LIANG Ren-xiang,LI Yun-xi,et al.
    2009, 1 (04):  310-312. 
    Abstract ( 157 )   Save
    Objective To investigate the incidence trend of gastric cancer in Fusui County.Methods The gastric cancer incidence was analyzed by using the data from cancer registration in Fusui County from 1974 to 2005.Results The crude incidences of gastric cancer in Fusui male and female were 12.71/105 and 5.41/105 respectively.While the incidences of gastric cancer adjusted by Chinese standard population were 11.47/105 in male and 4.88/105 in female,and the incidences adjusted by world standard population were 18.88/105 in male and 6.45/105 in female.Conclusions The increasing trend in incidence of gastric cancer in Fusui male form 1974 to 2005 is obvious.
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    Analysis of incidence trend of gastric cancer in Fusui County from 1974 to 2005
    WEI Zhong-liang,LIANG Ren-xiang,LI Yun-xi,et al.
    2009, 1 (04):  310-312. 
    Abstract ( 57 )   Save
    Objective To investigate the incidence trend of gastric cancer in Fusui County.Methods The gastric cancer incidence was analyzed by using the data from cancer registration in Fusui County from 1974 to 2005.Results The crude incidences of gastric cancer in Fusui male and female were 12.71/105 and 5.41/105 respectively.While the incidences of gastric cancer adjusted by Chinese standard population were 11.47/105 in male and 4.88/105 in female,and the incidences adjusted by world standard population were 18.88/105 in male and 6.45/105 in female.Conclusions The increasing trend in incidence of gastric cancer in Fusui male form 1974 to 2005 is obvious.
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    Dose-volume histogram analysis on radiation-induced liver disease (RILD) after conformal radiotherapy for primary liver carcinoma
    HUANG Hua-zhong,LI Ye-fei,LIANG Shi-xiong.
    2009, 1 (04):  313-317. 
    Abstract ( 132 )   Save
    Objective Radiation-induced liver disease (RILD) has been considered as the most severe complication in liver irradiation.However,RILD does not have effective predictors.This study was to identify dosimetric predictors for RILD in primary liver carcinoma (PLC) patients with Child-Pugh grade A cirrhosis after being treated with hypofractionated conformal radiotherapy (CRT).Methods Between August 2000 and June 2007,a total of 114 eligible patients were included.The median age was 45 years (23~79 years).Portal vein thrombosis (PVT) was detected in 22 patients.The mean gross tumor volume (GTV) was (378.3 ± 308.1) cm3.A median dose of 53 Gy (40~68 Gy) was delivered to the PLC by hypofractionated CRT (three fractions per week) with a median fraction size of 4.6 Gy (4~6 Gy).Thirty-eight patients had previously received transcatheter arterial chemoembolization.All patients had intact treatment planning data,including liver dose-volume histograms before treatment.Results Patients were followed up for 1-79 months (median 19 months) after completion of the irradiation.RILD was diagnosed in 9 (7.9%) patients.Univariate analyses revealed that GTV and the percent of normal liver volume exceeding 5-40 Gy (V5-40) were related to the risk of developing RILD.Multivariate analyses showed that only GTV (P=0.015) and V20 (P=0.003) were independent predictors.When using V20= 48.5% as tolerated dose to predict RILD,the accuracy,sensitivity and specificity was 76.3%,88.9% and 75.2%,respectively.Conclusions V20 is a unique significant dosimetric predictor to evaluate RILD risks for PLC patients with Child-Pugh grade A cirrhosis after hypofractionated CRT.
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    Dose-volume histogram analysis on radiation-induced liver disease (RILD) after conformal radiotherapy for primary liver carcinoma
    HUANG Hua-zhong,LI Ye-fei,LIANG Shi-xiong.
    2009, 1 (04):  313-317. 
    Abstract ( 61 )   Save
    Objective Radiation-induced liver disease (RILD) has been considered as the most severe complication in liver irradiation.However,RILD does not have effective predictors.This study was to identify dosimetric predictors for RILD in primary liver carcinoma (PLC) patients with Child-Pugh grade A cirrhosis after being treated with hypofractionated conformal radiotherapy (CRT).Methods Between August 2000 and June 2007,a total of 114 eligible patients were included.The median age was 45 years (23~79 years).Portal vein thrombosis (PVT) was detected in 22 patients.The mean gross tumor volume (GTV) was (378.3 ± 308.1) cm3.A median dose of 53 Gy (40~68 Gy) was delivered to the PLC by hypofractionated CRT (three fractions per week) with a median fraction size of 4.6 Gy (4~6 Gy).Thirty-eight patients had previously received transcatheter arterial chemoembolization.All patients had intact treatment planning data,including liver dose-volume histograms before treatment.Results Patients were followed up for 1-79 months (median 19 months) after completion of the irradiation.RILD was diagnosed in 9 (7.9%) patients.Univariate analyses revealed that GTV and the percent of normal liver volume exceeding 5-40 Gy (V5-40) were related to the risk of developing RILD.Multivariate analyses showed that only GTV (P=0.015) and V20 (P=0.003) were independent predictors.When using V20= 48.5% as tolerated dose to predict RILD,the accuracy,sensitivity and specificity was 76.3%,88.9% and 75.2%,respectively.Conclusions V20 is a unique significant dosimetric predictor to evaluate RILD risks for PLC patients with Child-Pugh grade A cirrhosis after hypofractionated CRT.
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    Superselective transarterial ethonal embolization with ethanol-lipiodol mixture for advanced hepatocellular carcinoma
    HUANG De-jia,MA Yi-long,KANG Ping,et al.
    2009, 1 (04):  318-321. 
    Abstract ( 122 )   Save
    Objective To evaluate the treatment effect of transarterial ethonal embolization with ethanol-lipiodol mixture for hepatocellular carcinomas (HCC) and its side effects,compared to conventional chemoembolization.Methods A case-controlled study was undertaken with 20 patients in each group,matched on tumor characteristics,Child-Pugh grade,performance status and the times of treatment. The experimental group was treated with transarterial ethanol ablation with the ethanol-lipiodol mixture in a ratio of 1:1,and the control group was treated with chemoembolization. The side effects of the therapy were recorded after operation. The effectiveness of the two treatments were evaluated by the parameters such as tumor necrosis,tumor response,disease progression,survival rate and overall survival.Result In the TEA group,4 patients achieved complete tumor necrosis,14 patients showed the tumor necrosis area >60%. While in the matched controls,there were none complete tumor necrosis and 9 patients had tumor necrosis >60% (P=0.001). the side effects such as fever,stomachache and vomit caused by arterial embolization between the two groups were not different (P>0.05). The incidence rate of bone marrow depression was higher in the control group (P<0.05). The median survival in TEA group was 26 months,while it was 21 months in TACE group. The accumulative survival rate of 1 year,2 years and the response rate (CR+PR) were 90%,60% and 55% respectively in TEA group,while were 70%,35% and 30% respectively in TACE group. the total survival with the long-rank test was significantly different between the two groups. Conclusion Superselective transarterial ethonal embolization with ethanol-lipiodol mixture possesses markedly stronger anticancerous effect and lower incidence rate of bone marrow depression,and its long-term effectiveness is superior to conventional TACE.
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    Superselective transarterial ethonal embolization with ethanol-lipiodol mixture for advanced hepatocellular carcinoma
    HUANG De-jia,MA Yi-long,KANG Ping,et al.
    2009, 1 (04):  318-321. 
    Abstract ( 58 )   Save
    Objective To evaluate the treatment effect of transarterial ethonal embolization with ethanol-lipiodol mixture for hepatocellular carcinomas (HCC) and its side effects,compared to conventional chemoembolization.Methods A case-controlled study was undertaken with 20 patients in each group,matched on tumor characteristics,Child-Pugh grade,performance status and the times of treatment. The experimental group was treated with transarterial ethanol ablation with the ethanol-lipiodol mixture in a ratio of 1:1,and the control group was treated with chemoembolization. The side effects of the therapy were recorded after operation. The effectiveness of the two treatments were evaluated by the parameters such as tumor necrosis,tumor response,disease progression,survival rate and overall survival.Result In the TEA group,4 patients achieved complete tumor necrosis,14 patients showed the tumor necrosis area >60%. While in the matched controls,there were none complete tumor necrosis and 9 patients had tumor necrosis >60% (P=0.001). the side effects such as fever,stomachache and vomit caused by arterial embolization between the two groups were not different (P>0.05). The incidence rate of bone marrow depression was higher in the control group (P<0.05). The median survival in TEA group was 26 months,while it was 21 months in TACE group. The accumulative survival rate of 1 year,2 years and the response rate (CR+PR) were 90%,60% and 55% respectively in TEA group,while were 70%,35% and 30% respectively in TACE group. the total survival with the long-rank test was significantly different between the two groups. Conclusion Superselective transarterial ethonal embolization with ethanol-lipiodol mixture possesses markedly stronger anticancerous effect and lower incidence rate of bone marrow depression,and its long-term effectiveness is superior to conventional TACE.
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    Observation on efficacy of combined organ resection for treating advanced gastric cancer
    XU Guo-ding and HAN Wei.
    2009, 1 (04):  322-323. 
    Abstract ( 99 )   Save
    Objective To explore the significance and effect of combined evisceration for treating advanced gastric cancer.Methods Clinical data of 62 cases of advanced gastric cancer from June 1995 to June 2008 were analyzed retrospectively.Group A included 32 cases treated by combined organ resection,and group B included 30 cases treated by palliative resection.Patients in both groups received same chemotherapy and immunotherapy after surgery,none had radiotherapy.Results The 1-,3-and 5-year survival rate in group A were 59.4%,42.5% and 21.9% respectively,while the rates in group B were 30%,0 and 0 respectively.Differences between the two groups were significant.The surgical complications in group A were more than that in group B but were curable.Conclusion Combined organ resection is practicable for treating advanced gastric cancer.
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    Observation on efficacy of combined organ resection for treating advanced gastric cancer
    XU Guo-ding and HAN Wei.
    2009, 1 (04):  322-323. 
    Abstract ( 63 )   Save
    Objective To explore the significance and effect of combined evisceration for treating advanced gastric cancer.Methods Clinical data of 62 cases of advanced gastric cancer from June 1995 to June 2008 were analyzed retrospectively.Group A included 32 cases treated by combined organ resection,and group B included 30 cases treated by palliative resection.Patients in both groups received same chemotherapy and immunotherapy after surgery,none had radiotherapy.Results The 1-,3-and 5-year survival rate in group A were 59.4%,42.5% and 21.9% respectively,while the rates in group B were 30%,0 and 0 respectively.Differences between the two groups were significant.The surgical complications in group A were more than that in group B but were curable.Conclusion Combined organ resection is practicable for treating advanced gastric cancer.
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    Efficacy of Oxaliplatin combined with Vinorelbine or Gemcitabine on Cisplatin-and Taxane-resistant or refractory advanced non-small cell lung cancer
    KANG Ma-fei,LUO Mei-qing,LI Bi-hui,et al.
    2009, 1 (04):  324-326. 
    Abstract ( 132 )   Save
    Objective To observe the efficacy of Oxaliplatin (OXA) combined with Vinorelbine (NVB) or Gemcitabine (GEM) on Cisplatin (DDP) plus Paclitaxel (PTX) or Docetaxel (DOC) resistant or refractory advanced non-small cell lung cancer (NSCLC).Methods Sixty patients with DDP plus PTX or DOC resistant or refractory NSCLC were divided randomly into group NO (NVB plus OXA) and group GEMOX (GEM plus OXA).Thirty patients in group NO were treated with NVB 25mg/m2 at d1 and d8,and OXA 100mg/m2 at d1.Thirty patients in group GEMOX were treated with GEM 1000mg/m2 at d1 and d8,and OXA 100mg/m2 at d1.The drugs were given intravenously,and the treatments were repeated once every three weeks.Results In group NO,five patients achieved a partial response (PR),thirteen patients achieved a stable disease (SD),and twelve patients achieved a progress disease (PD).The overall response rate (ORR) was 16.7%,the disease control rate (DCR) was 60.0%,and the time to progression (TTP) was 3.3 months.In group GEMOX,6 patients achieved PR,11 patients achieved SD,13 patients achieved PD.The ORR was 20.0%,the DCR was 56.7%,and the TTP was 3.4 months.There was no significantly statistic difference between group NO and group GEMOX.The major adverse effects in both groups were neutropenia and peripheral sensory neuropathy,and there was no significantly statistic difference between the two groups either.Conclusions It is effective to treat DDP and PTX or DOC resistant or refractory advanced NSCLC by OXA combined with NVB or GEM.
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    Efficacy of Oxaliplatin combined with Vinorelbine or Gemcitabine on Cisplatin-and Taxane-resistant or refractory advanced non-small cell lung cancer
    KANG Ma-fei,LUO Mei-qing,LI Bi-hui,et al.
    2009, 1 (04):  324-326. 
    Abstract ( 82 )   Save
    Objective To observe the efficacy of Oxaliplatin (OXA) combined with Vinorelbine (NVB) or Gemcitabine (GEM) on Cisplatin (DDP) plus Paclitaxel (PTX) or Docetaxel (DOC) resistant or refractory advanced non-small cell lung cancer (NSCLC).Methods Sixty patients with DDP plus PTX or DOC resistant or refractory NSCLC were divided randomly into group NO (NVB plus OXA) and group GEMOX (GEM plus OXA).Thirty patients in group NO were treated with NVB 25mg/m2 at d1 and d8,and OXA 100mg/m2 at d1.Thirty patients in group GEMOX were treated with GEM 1000mg/m2 at d1 and d8,and OXA 100mg/m2 at d1.The drugs were given intravenously,and the treatments were repeated once every three weeks.Results In group NO,five patients achieved a partial response (PR),thirteen patients achieved a stable disease (SD),and twelve patients achieved a progress disease (PD).The overall response rate (ORR) was 16.7%,the disease control rate (DCR) was 60.0%,and the time to progression (TTP) was 3.3 months.In group GEMOX,6 patients achieved PR,11 patients achieved SD,13 patients achieved PD.The ORR was 20.0%,the DCR was 56.7%,and the TTP was 3.4 months.There was no significantly statistic difference between group NO and group GEMOX.The major adverse effects in both groups were neutropenia and peripheral sensory neuropathy,and there was no significantly statistic difference between the two groups either.Conclusions It is effective to treat DDP and PTX or DOC resistant or refractory advanced NSCLC by OXA combined with NVB or GEM.
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    Clinical analysis on 30 cases of esthesioneuroblastoma
    ZHENG Fei,ZHANG Yu,ZHENG Zhuo,et al.
    2009, 1 (04):  327-329. 
    Abstract ( 198 )   Save
    Objective To Study the correlation between prognostic factors and clinical features as well as treatment approaches of esthesioneuroblastoma (ENB).Methods Clinical data of 30 ENB patients treated at our hospital from Jan 1992 to May 2007 were analyzed retrospectively.The correlation between prognostic factors and clinical features as well as treatment approaches was analyzed by Kaplan-Meier method.Results The 5-year overall survival (OS) of the whole group was 43.3%.The 5-year OS of the subgroups of Kadish stage A+B and stage C were 80% and 25% respectively,the difference between the two subgroups was statistically significant (P<0.05).The 5-year OS of the subgroups with and without cervical lymph node metastasis were 25% and 55.6% respectively,which was statistically significant (P<0.05).The 5-year OS of the subgroups treated by surgery,radiotherapy,chemotherapy,surgery combined with chemoradiotherapy and chemoradiotherapy only were 0,33.3%,33.3%,52.9% and 33.3%,respectively,the differences among these subgroups were not statistically significant.The 5-year OS of the subgroups with and without intracalvarium invasion were 21.4% and 62.5% respectively,which was statistically significant (P<0.05).The 5-year OS of the subgroups of age ≥50 and <50 were 23.1% and 58.8% respectively,which was statistically significant (P<0.05).Conclusions Prognosis of ENB is associated with patient's age,clinical stage,cervical lymph nodal metastasis and intracalvarium invasion.
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    Clinical analysis on 30 cases of esthesioneuroblastoma
    ZHENG Fei,ZHANG Yu,ZHENG Zhuo,et al.
    2009, 1 (04):  327-329. 
    Abstract ( 84 )   Save
    Objective To Study the correlation between prognostic factors and clinical features as well as treatment approaches of esthesioneuroblastoma (ENB).Methods Clinical data of 30 ENB patients treated at our hospital from Jan 1992 to May 2007 were analyzed retrospectively.The correlation between prognostic factors and clinical features as well as treatment approaches was analyzed by Kaplan-Meier method.Results The 5-year overall survival (OS) of the whole group was 43.3%.The 5-year OS of the subgroups of Kadish stage A+B and stage C were 80% and 25% respectively,the difference between the two subgroups was statistically significant (P<0.05).The 5-year OS of the subgroups with and without cervical lymph node metastasis were 25% and 55.6% respectively,which was statistically significant (P<0.05).The 5-year OS of the subgroups treated by surgery,radiotherapy,chemotherapy,surgery combined with chemoradiotherapy and chemoradiotherapy only were 0,33.3%,33.3%,52.9% and 33.3%,respectively,the differences among these subgroups were not statistically significant.The 5-year OS of the subgroups with and without intracalvarium invasion were 21.4% and 62.5% respectively,which was statistically significant (P<0.05).The 5-year OS of the subgroups of age ≥50 and <50 were 23.1% and 58.8% respectively,which was statistically significant (P<0.05).Conclusions Prognosis of ENB is associated with patient's age,clinical stage,cervical lymph nodal metastasis and intracalvarium invasion.
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    Clinical analysis on 16 cases of advanced pancreatic cancer treated with color Doppler ultrasound-guided laparotomy for iodine ~(125) implantation
    ZHANG You-xun,MA Xiu-ping,LAN Chuan-xin.
    2009, 1 (04):  330-332. 
    Abstract ( 117 )   Save
    Objective To analyze the efficacy and complications of the treatment on advanced pancreatic cancer with color Doppler ultrasound-guided laparotomy for iodine125 implantation.Methods Retrospectively analyzed 16 patients with advanced pancreatic cancer.The radiation particles numbers were scheduled preoperatively by three-dimensional directional line treatment planning system (TPS).After abdominal exploration,the pancreatic cancer was confirmed by puncture biopsy.Color Doppler ultrasound-guided iodine125 interstitial brachytherapy was operated under direct vision.Taking abdominal incision to expose the pancreatic cancer,color Doppler ultrasound was used to determine the direction and scope of the needle,and the particle gun was used to implant particles.Attention was paid to protect blood vessels,pancreatic channel and gallbladder channel.There were 7 case of choledochoduodenostomy and 5 cases of gastrojejunostomy.Abdominal X or CT scan was performed two weeks later.Results 11 cases with pain symptom were completely or partially relieved.The effective time was 2-50 days,with a median onset time of 10 days.Reexamine at two weeks after operation showed that 1 case had two particles wandered into liver,2 cases had pancreatic fistula,3 cases had obstacle in gastric emptying.Conclusions The treatment of color Doppler ultrasound-guided laparotomy for iodine125 implantation on advanced pancreatic cancer has the advantages at accurate positioning,uniform particle arrangement,less complications and better analgesic effect.Some patients can have improved life quality and prolonged survival time after the treatment.
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    Clinical analysis on 16 cases of advanced pancreatic cancer treated with color Doppler ultrasound-guided laparotomy for iodine ~(125) implantation
    ZHANG You-xun,MA Xiu-ping,LAN Chuan-xin.
    2009, 1 (04):  330-332. 
    Abstract ( 97 )   Save
    Objective To analyze the efficacy and complications of the treatment on advanced pancreatic cancer with color Doppler ultrasound-guided laparotomy for iodine125 implantation.Methods Retrospectively analyzed 16 patients with advanced pancreatic cancer.The radiation particles numbers were scheduled preoperatively by three-dimensional directional line treatment planning system (TPS).After abdominal exploration,the pancreatic cancer was confirmed by puncture biopsy.Color Doppler ultrasound-guided iodine125 interstitial brachytherapy was operated under direct vision.Taking abdominal incision to expose the pancreatic cancer,color Doppler ultrasound was used to determine the direction and scope of the needle,and the particle gun was used to implant particles.Attention was paid to protect blood vessels,pancreatic channel and gallbladder channel.There were 7 case of choledochoduodenostomy and 5 cases of gastrojejunostomy.Abdominal X or CT scan was performed two weeks later.Results 11 cases with pain symptom were completely or partially relieved.The effective time was 2-50 days,with a median onset time of 10 days.Reexamine at two weeks after operation showed that 1 case had two particles wandered into liver,2 cases had pancreatic fistula,3 cases had obstacle in gastric emptying.Conclusions The treatment of color Doppler ultrasound-guided laparotomy for iodine125 implantation on advanced pancreatic cancer has the advantages at accurate positioning,uniform particle arrangement,less complications and better analgesic effect.Some patients can have improved life quality and prolonged survival time after the treatment.
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    The interference effect of Chinese herbal compound on Oxaliplatin-induced neurotoxicity
    LIN Yan,XU You-qi,DING Rong.
    2009, 1 (04):  333-334. 
    Abstract ( 137 )   Save
    Objective To observe the antagonism of Chinese medicine Yiqi Huoxue for Oxaliplatin-induced neurotoxicity.Methods 54 cases of cancer patients accepted Oxaliplatin chemotherapy were divided into treatment and control groups.Patients in the treatment group were treated with both Oxaliplatin chemotherapy and Chinese medicine Yiqi Huoxue,and patients in control groups were treated with oxaliplatin chemotherapy only.Results The clinical effect was similar in the two groups.However,the occurrence rate and degree of neurotoxicity were lower in treatment group than that in control group.Conclusions Chinese medicine Yiqi Huoxue can intervene and antagonize Oxaliplatin-induced neurotoxicity.
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    The interference effect of Chinese herbal compound on Oxaliplatin-induced neurotoxicity
    LIN Yan,XU You-qi,DING Rong.
    2009, 1 (04):  333-334. 
    Abstract ( 68 )   Save
    Objective To observe the antagonism of Chinese medicine Yiqi Huoxue for Oxaliplatin-induced neurotoxicity.Methods 54 cases of cancer patients accepted Oxaliplatin chemotherapy were divided into treatment and control groups.Patients in the treatment group were treated with both Oxaliplatin chemotherapy and Chinese medicine Yiqi Huoxue,and patients in control groups were treated with oxaliplatin chemotherapy only.Results The clinical effect was similar in the two groups.However,the occurrence rate and degree of neurotoxicity were lower in treatment group than that in control group.Conclusions Chinese medicine Yiqi Huoxue can intervene and antagonize Oxaliplatin-induced neurotoxicity.
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