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中国癌症防治杂志

中国癌症防治杂志 ›› 2011, Vol. 3 ›› Issue (4): 277-280.doi: 10.3969/j.issn.1674-5671.2011.04.02

• 基础研究 • 上一篇    下一篇

IGF-1R基因多态性与原发性肝癌易感性的相关性研究

秦艳霞, 黄天壬, 邓伟, 余家华, 张春燕, 利基林   

  1. 广西医科大学附属肿瘤医院实验研究部；△广西医科大学研究生学院
  • 出版日期:2011-12-25 发布日期:2012-01-20
  • 通讯作者: 黄天壬 E-mail:tianrenhuang@yahoo.com.cn
  • 基金资助:

    国家自然科学基金项目（30960333）；广西自然科学基金资助项目（桂科自0991017Z）

Correlation between IGF-1R polymorphism and genetic susceptibility to hepatocellular carcinoma

QIN Yan-Xia, HUANG Tian-Ren, DENG Wei, YU Jia-Hua, ZHANG Chun-Yan, LI Ji-Lin   

  • Online:2011-12-25 Published:2012-01-20

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被引次数

4

摘要： 目的 探讨广西肝癌高发区肝癌相关基因IGF-1R基因多态性与原发性肝癌易感性的关系。方法  采用病例对照研究方法，在广西肝癌高发现场人群中选取113例原发性肝癌及113名健康对照人群。以筛选IGF-1R基因SNP rs 61740868位点为遗传标志，采用聚合酶链式反应-限制性片段长度多态性方法（PCR-RFLP法）检测IGF-1R基因rs 61740868多态性及其基因分布的频率。结果 肝癌病例组与对照组IGF-1R基因rs 61740868位点均未发生基因突变，其基因型均为CC型，两组比较差异无统计学意义（P＞0.05）。  结论 IGF-1R基因rs 61740868位点多态性与肝癌发生无关，可能不是肝癌的危险因素之一。

关键词: 原发性肝癌, IGF-1R基因, 单核苷酸多态性

Abstract: Objective To explore the correlation between IGF-1R polymorphism and genetic susceptibility to hepatocellular carcinoma (HCC) in the area with high incidence of HCC in Guangxi.Methods A case-control study was conducted which included 113 HCC patients and 113 normal controls.All of the cases were from the areas with high incidence of HCC in Guangxi.The SNP locus rs 61740868 of gene IGF-1R was selected as a genetic marker，and its genotypes as well as mutation frequency were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results There was no mutation in SNP locus rs 61740868 of IGF-1R in both HCC cases and controls.The expressions of IGF-1R were not statistically different between the two groups (P＞0.05).Conclusion Polymorphism of IGF-1R SNP locus rs 61740868 is not associated with HCC，it may not be a risk factor for HCC.

Key words: Hepatocellular carcinoma, Insulin-like growth factor 1 receptor (IGF-1R), Single nucleotide polymorphism