Abstract: Objective To analyze the characteristics of the incidence and mortality of thyroid cancer in Guangxi cancer registration areas in 2019 and evaluate their trends from 2012 to 2019. Methods According to relevant quality control standards, the incidence and death data of thyroid cancer from 56 tumor registries meeting the quality control requirements in Guangxi from 2012 to 2019， and the crude incidence rate, crude mortality rate and standardized rate were calculated according to age, gender and region,  respectively.  The annual average percentage change (AAPC) was calculated by Joinpoint regression model to analyze the trends of thyroid cancer from 2012 to 2019. Results In 2019, Guangxi registries reported 2,282 new thyroid cancer cases, with age⁃standardized incidence rate by Chinese standard population (ASIRC) of 6.49/10⁵, and reported 137 deaths, with age⁃standardized mortality rate by Chinese standard population (ASMRC) of 0.32/10⁵. The ASIRC of thyroid cancer in females (10.36/10⁵) was 3.6 times higher than in males (2.89/10⁵), with slightly higher female ASMRC (0.38 /105 vs  0.25/10⁵). Urban areas showed significantly higher ASIRC and ASMRC of thyroid cancer (9.45/10⁵ and 0.39/105) than in rural areas (4.46/105 and 0.27/105).  The peak incidence and mortality rates were in the 50-59 and 70-79 age groups, respectively. From 2012 to 2019, the ASIRC of thyroid cancer in Guangxi showed an upward trend (AAPC=13.68%, P<0.001),  particularly in females, males, and urban populations (all P<0.05). However, there was no significant change in ASMRC (AAPC=-4.94%, P=0.116). Conclusions The incidence of thyroid cancer in Guangxi demonstrates an upward trend from 2012 to 2019, with higher rates observed in urban areas, females, and middle⁃aged and young populations, though the mortality rate remains relatively stable. Efforts should be enhanced to prevent and control thyroid cancer by conducting multi⁃dimensional health education and implementing targeted precision screening strategies. 

Key words: Thyroid cancer, Incidence rate, Mortality rate, Trend, Guangxi